Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK1	HIF1A	Ser641	DIKILIAsPSPTHIH	phosphorylation up-regulates	18519666	SIGNOR-178723
ATM	HIF1A	Ser696	NVLSVALsQRTTVPE	phosphorylation up-regulates	21095582	SIGNOR-169999
CSNK1D	HIF1A	Ser247	KTFLSRHsLDMKFSY	phosphorylation down-regulates	20699359	SIGNOR-167476
MAPK3	HIF1A	Ser643 View in OncoXplorer	KILIASPsPTHIHKE	phosphorylation up-regulates	18519666	SIGNOR-178735
MAPK1	HIF1A	Ser643 View in OncoXplorer	KILIASPsPTHIHKE	phosphorylation up-regulates	18519666	SIGNOR-178727
CDK1	HIF1A	Ser668	DTQSRTAsPNRAGKG	phosphorylation up-regulates activity	24189531	SIGNOR-279599
CDK5	HIF1A	Ser687	TEKSHPRsPNVLSVA	phosphorylation up-regulates activity	27027353	SIGNOR-279020
CSNK2A1	HIF1A	Thr796	ESGLPQLtSYDCEVN	phosphorylation unknown	17382325	SIGNOR-250891
PLK3	HIF1A	Ser657	ETTSATSsPYRDTQS	phosphorylation down-regulates	18519666	SIGNOR-178743
MAPK3	HIF1A	Ser641	DIKILIAsPSPTHIH	phosphorylation up-regulates	18519666	SIGNOR-178731
PLK3	HIF1A	Ser576	DDDFQLRsFDQLSPL	phosphorylation down-regulates	18519666	SIGNOR-178739
ERK1/2	HIF1A	–		phosphorylation up-regulates	18519666	SIGNOR-270191
PIM1	HIF1A	Thr455	LAMSPLPtAETPKPL	phosphorylation up-regulates quantity by stabilization	34211090	SIGNOR-277311
Gbeta	HIF1A	–		phosphorylation up-regulates	18519666	SIGNOR-270095
GSK3B	HIF1A	Ser551	TEAKNPFsTQDTDLD	phosphorylation down-regulates activity	23210979	SIGNOR-278294

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK1	phosphorylation up-regulates →	HIF1A PSer641	phosphorylation up-regulates →	HIF1A	18519666	SIGNOR-178723
ATM	phosphorylation up-regulates →	HIF1A PSer696	phosphorylation up-regulates →	HIF1A	21095582	SIGNOR-169999
CSNK1D	phosphorylation up-regulates →	HIF1A PSer247	phosphorylation down-regulates ⊣	HIF1A	20699359	SIGNOR-167476
MAPK3	phosphorylation up-regulates →	HIF1A PSer643	phosphorylation up-regulates →	HIF1A	18519666	SIGNOR-178735
MAPK1	phosphorylation up-regulates →	HIF1A PSer643	phosphorylation up-regulates →	HIF1A	18519666	SIGNOR-178727
CDK1	phosphorylation up-regulates →	HIF1A PSer668	phosphorylation up-regulates →	HIF1A	24189531	SIGNOR-279599
CDK5	phosphorylation up-regulates →	HIF1A PSer687	phosphorylation up-regulates →	HIF1A	27027353	SIGNOR-279020
CSNK2A1	phosphorylation up-regulates →	HIF1A PThr796	phosphorylation down-regulates ⊣	HIF1A	17382325	SIGNOR-250891
PLK3	phosphorylation up-regulates →	HIF1A PSer657	phosphorylation down-regulates ⊣	HIF1A	18519666	SIGNOR-178743
MAPK3	phosphorylation up-regulates →	HIF1A PSer641	phosphorylation up-regulates →	HIF1A	18519666	SIGNOR-178731
PLK3	phosphorylation up-regulates →	HIF1A PSer576	phosphorylation down-regulates ⊣	HIF1A	18519666	SIGNOR-178739
PIM1	phosphorylation up-regulates →	HIF1A PThr455	phosphorylation up-regulates →	HIF1A	34211090	SIGNOR-277311
GSK3B	phosphorylation up-regulates →	HIF1A PSer551	phosphorylation down-regulates ⊣	HIF1A	23210979	SIGNOR-278294

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK1	phosphorylation → up-regulates	HIF1A	SIGNOR-178723
ATM	phosphorylation → up-regulates	HIF1A	SIGNOR-169999
CSNK1D	phosphorylation down-regulates	HIF1A	SIGNOR-167476
MAPK3	phosphorylation → up-regulates	HIF1A	SIGNOR-178735
MAPK1	phosphorylation → up-regulates	HIF1A	SIGNOR-178727
CDK1	phosphorylation → up-regulates activity	HIF1A	SIGNOR-279599
CDK5	phosphorylation → up-regulates activity	HIF1A	SIGNOR-279020
CSNK2A1	phosphorylation → unknown	HIF1A	SIGNOR-250891
PLK3	phosphorylation down-regulates	HIF1A	SIGNOR-178743
MAPK3	phosphorylation → up-regulates	HIF1A	SIGNOR-178731
PLK3	phosphorylation down-regulates	HIF1A	SIGNOR-178739
ERK1/2	phosphorylation → up-regulates	HIF1A	SIGNOR-270191
PIM1	phosphorylation → up-regulates quantity by stabilization	HIF1A	SIGNOR-277311
Gbeta	phosphorylation → up-regulates	HIF1A	SIGNOR-270095
GSK3B	phosphorylation → down-regulates activity	HIF1A	SIGNOR-278294