Summary

Name HIF1A
Full Name Hypoxia-inducible factor 1-alpha
Synonyms HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8 | BHLHE78, MOP1, PASD8
Primary ID Q16665
Links - -
Type protein
Relations 40
Pathways NOTCH Signaling
Function Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation HIF1A 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HIF1A 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HIF1A 0.14
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALDOA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL1B 0.31
Publications: 3 Organism: Mus Musculus
+ up-regulates img/direct-activation.png desumoylation HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EPO 0.2
Publications: 1
+ up-regulates img/direct-activation.png sumoylation HIF1A 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization HIF1A 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALAS2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epithelial-Mesenchymal Transition 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NT5E 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PGK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HIF1A 0.28
Publications: 1
+ up-regulates img/indirect-activation.png HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Metabolism 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png glycolysis 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional activation VEGFA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination HIF1A 0.61
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity img/direct-activation.png transcriptional activation EPO 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png HIF1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HIF1A 0.31
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation CD274 0.14
Publications: 1 Organism: Homo Sapiens