Summary

Name HIF1A
Full Name Hypoxia-inducible factor 1-alpha
Synonyms HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8 | BHLHE78, MOP1, PASD8
Primary ID Q16665
Links - -
Type protein
Relations 76
Pathways Macrophage: IL1 beta transcriptional regulation, NOTCH Signaling
Function Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HIF1A 0.325
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HIF1A 0.333
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HIF1A 0.349
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.584
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.695
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HIF1A 0.342
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PGK1 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KDM4B 0.262
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding HIF-1 complex 0.786
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png acetylation HIF1A 0.513
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM4B 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EPO 0.642
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM4C 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM2B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM5C 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png desumoylation HIF1A 0.326
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.337
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation VEGFA 0.773
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM3A 0.416
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HIF1A 0.459
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation EPO 0.642
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NT5E 0.292
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination HIF1A 0.377
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation HIF1A 0.459
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL1B 0.337
Publications: 3 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding HIF1A 0.327
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png hydroxylation HIF1A 0.918
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM5B 0.272
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM7A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STC2 0.298
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png hydroxylation HIF1A 0.797
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCL2 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png HIF1A 0.257
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TM9SF4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM2A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HIF1A 0.786
Publications: 1
+ down-regulates quantity by destabilization img/indirect_inhibition.png HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination HIF1A 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HIF1A 0.522
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Glycolysis 0.7
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PDK1 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM5A 0.273
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates img/indirect-activation.png Epithelial-mesenchymal_transition 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png HIF1A 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD274 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HIF1A 0.8
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination HIF1A 0.641
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation KDM1A 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png HIF1A 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PKG 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FAM162A 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization HIF1A 0.648
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png hydroxylation HIF1A 0.856
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM6B 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HIF1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALAS2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Metabolism 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALDOA 0.337
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png HIF1A 0.362
Publications: 1 Organism: Homo Sapiens