| + |
CSNK1D | down-regulates 
phosphorylation
|
HIF1A |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167476 |
Ser247 |
KTFLSRHsLDMKFSY |
Homo sapiens |
|
| pmid |
sentence |
| 20699359 |
In this work, we investigate the phosphorylation of the n-terminal heterodimerization (pas) domain of hif-1alpha and identify ser247 as a major site of in vitro modification by casein kinase 1delta (ck1delta). Mutation of this site to alanine, surprisingly, enhanced the transcriptional activity of hif-1alpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK3 | down-regulates
phosphorylation
|
HIF1A |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178739 |
Ser576 |
DDDFQLRsFDQLSPL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18519666 |
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditionsplk3 can potentially inhibit hif-1_ by physical interaction and direct phosphorylation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178743 |
Ser657 |
ETTSATSsPYRDTQS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18519666 |
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditionsplk3 can potentially inhibit hif-1_ by physical interaction and direct phosphorylation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates 
phosphorylation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178731 |
Ser641 |
DIKILIAsPSPTHIH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18519666 |
We show that at least two different nuclear protein kinases, one of them identified as p42/p44 mapk, can modify hif-1_. Analysis of in vitro phosphorylated hif-1_ by mass spectroscopy revealed residues ser-641 and ser-643 as possible mapk phosphorylation sites these data suggest that phosphorylation of ser-641/643 by mapk promotes the nuclear accumulation and transcriptional activity of hif-1_ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178735 |
Ser643 |
KILIASPsPTHIHKE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18519666 |
We show that at least two different nuclear protein kinases, one of them identified as p42/p44 mapk, can modify hif-1_. Analysis of in vitro phosphorylated hif-1_ by mass spectroscopy revealed residues ser-641 and ser-643 as possible mapk phosphorylation sites these data suggest that phosphorylation of ser-641/643 by mapk promotes the nuclear accumulation and transcriptional activity of hif-1_ |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
phosphorylation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178723 |
Ser641 |
DIKILIAsPSPTHIH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18519666 |
We show that at least two different nuclear protein kinases, one of them identified as p42/p44 mapk, can modify hif-1_. Analysis of in vitro phosphorylated hif-1_ by mass spectroscopy revealed residues ser-641 and ser-643 as possible mapk phosphorylation sites these data suggest that phosphorylation of ser-641/643 by mapk promotes the nuclear accumulation and transcriptional activity of hif-1_ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178727 |
Ser643 |
KILIASPsPTHIHKE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18519666 |
We show that at least two different nuclear protein kinases, one of them identified as p42/p44 mapk, can modify hif-1_. Analysis of in vitro phosphorylated hif-1_ by mass spectroscopy revealed residues ser-641 and ser-643 as possible mapk phosphorylation sites these data suggest that phosphorylation of ser-641/643 by mapk promotes the nuclear accumulation and transcriptional activity of hif-1_ |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates
phosphorylation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169999 |
Ser696 |
NVLSVALsQRTTVPE |
Homo sapiens |
|
| pmid |
sentence |
| 21095582 |
Here we show that hypoxia results in ataxia telangiectasia mutated (atm)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (hif-1_) on serine(696) and mediates downregulation of mtorc1 signaling. phosphorylation of hif-1_ by atm is required for its stability |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 |
phosphorylation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250891 |
Thr796 |
ESGLPQLtSYDCEVN |
in vitro |
|
| pmid |
sentence |
| 17382325 |
These results implied that only Thr-796 was phosphorylated CK2. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
EML4-ALK | up-regulates quantity by expression 
transcriptional activation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259172 |
|
|
Homo sapiens |
NCI-H23 Cell |
| pmid |
sentence |
| 27141364 |
EML4-ALK enhanced HIF-1α expression through increasing transcription and decreasing ubiquitination of HIF-1α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EML4-ALK | up-regulates quantity by stabilization
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259173 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27141364 |
EML4-ALK enhanced HIF-1α expression through increasing transcription and decreasing ubiquitination of HIF-1α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
ALDOA |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254422 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8955077 |
we characterize hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes. Our data establish that functional hypoxia-response elements consist of a pair of contiguous transcription factor binding sites at least one of which contains the core sequence 5'-RCGTG-3' and is recognized by HIF-1. These results provide further evidence that the coordinate transcriptional activation of genes encoding glycolytic enzymes which occurs in hypoxic cells is mediated by HIF-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
CCL2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251719 |
|
|
Homo sapiens |
Perivascular Astrocyte |
| pmid |
sentence |
| 17474992 |
These findings suggest that both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1α is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256235 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17548584 |
The loss of macrophage expression of HIF-1 led to significant decreases in the production of TNF-a, IL-1a, IL-1b, and IL-12 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256236 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25750431 |
The results of this study show that the absence of HIFs in MPs has no impact on the resolution of inflammation in two sterile models of skeletal muscle regeneration |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251718 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 24352507 |
We finally confirmed that in the absence of HIF-1α there was a significant reduction at the protein level in pro-caspase-1, activated caspase-1, pro-IL-1β, and ultimately active IL-1β (Fig. 4g and h). These data show that adenosine induced up-regulation of IL-1β is dependent on a CREB/HIF-1α pathway which is distinct from the NF-kB pathway used for initial production of IL-1β in response to LPS. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
SENP1 | up-regulates
desumoylation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158891 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17981124 |
Sumo-specific protease 1 is essential for stabilization of hif1alpha during hypoxia / our results support a model in which sumoylated hif1_ is unstable but can be stabilized when sumo is removed by senp1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
EPO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253695 |
|
|
|
|
| pmid |
sentence |
| 8663540 |
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) gene. |
|
| Publications: |
1 |
| + |
RWDD3 | up-regulates
sumoylation
|
HIF1A |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17956732 |
Rsume,_a small_rwd-containing protein, enhances sumo conjugation and stabilizes hif-1alpha during hypoxia |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH1 | up-regulates activity
relocalization
|
HIF1A |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141315 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16256737 |
The notch intracellular domain interacts with hif-1alpha and hif-1alpha is recruited to notch-responsive promoters upon notch activation under hypoxic conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
ABCB1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254420 |
|
|
Homo sapiens |
Microvascular Endothelial Cell |
| pmid |
sentence |
| 12067980 |
Examination of the MDR1 gene identified a binding site for hypoxia inducible factor-1 (HIF-1), and inhibition of HIF-1 expression by antisense oligonucleotides resulted in significant inhibition of hypoxia-inducible MDR1 expression and a nearly complete loss of basal MDR1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
ALAS2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254421 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 21207956 |
Hypoxia-induced expression of erythroid-specific ALAS2 is mediated by HIF1 in erythroid cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates
|
Epithelial-Mesenchymal Transition |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254768 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27476001 |
Our present study reveals that DAB2IP prevents EMT and metastasis of prostate cancer through targeting PROX1 gene transcription and destabilizing HIF1α protein, which provides a new insight into mechanism that DAB2IP regulates EMT and PCa metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PROX1 | up-regulates quantity by stabilization
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254766 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27476001 |
PROX1 is important to maintain HIF1α protein stability by inhibiting the proteasome activity after DAB2IP loss, since our immunoprecipitation data showed that knocking-down PROX1 could enhance the protein–protein interaction between HIF1α and ubiquitin in DAB2IP-deficient LAPC-4 and RWPE-1 KD cells. we found that knocking-down PROX1 could decrease HIF1α protein stability, because HIF1α protein degradation was significantly blocked by MG132 treatment in LAPC-4 and RWPE-1 KD cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
NT5E |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254423 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 12370277 |
Examination of the CD73 gene promoter identified at least one binding site for hypoxia-inducible factor-1 (HIF-1) and inhibition of HIF-1alpha expression by antisense oligonucleotides resulted in significant inhibition of hypoxia-inducible CD73 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
PGK1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254424 |
|
|
Homo sapiens |
HeLa Cell, HEP-3B Cell |
| pmid |
sentence |
| 8089148 |
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine). Sequences from the ALDA, PFKL, and PGK1 genes containing HIF-1 binding sites mediated hypoxia-inducible transcription in transient expression assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | up-regulates activity
binding
|
HIF1A |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253720 |
|
|
|
|
| pmid |
sentence |
| 14764593 |
The functional transcription factor exists as a heterodimeric complex consisting of HIF-1alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT). Association of HIF-1 with ARNT is required for its activity; however, no other role has been ascribed to this interaction. |
|
| Publications: |
1 |
| + |
SIAH2 | up-regulates
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149893 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17003045 |
The ring finger ubiquitin ligase siah2 controls the stability of various substrates involved in stress and hypoxia responses, including the phd3, which controls the stability of hif-1alpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149887 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17003045 |
The ring finger ubiquitin ligase siah2 controls the stability of various substrates involved in stress and hypoxia responses, including the phd3, which controls the stability of hif-1alpha. In the present study we determined the role of siah2 phosphorylation in the regulation of its activity toward phd3. We show that siah2 is subject to phosphorylation by p38 mapk, which increases siah2-mediated degradation of phd3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates
|
Metabolism |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17415528 |
HIF-1 has been known as a major transcription factor for the induction of virtually all genes encoding glucose transporters and glycolytic enzymes, which allows hypoxic tumor cells to take up glucose more efficiently and metabolize pyruvate to lactate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates
|
glycolysis |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259380 |
|
|
Homo sapiens |
Synovial Fibroblast |
| pmid |
sentence |
| 28623342 |
Our results demonstrate that SF(synovial fibroblasts) are highly dependent on glycolytic metabolism and that HIF-1α plays a regulatory role in glycolysis even under aerobic conditions. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17415528 |
HIF-1 has been known as a major transcription factor for the induction of virtually all genes encoding glucose transporters and glycolytic enzymes, which allows hypoxic tumor cells to take up glucose more efficiently and metabolize pyruvate to lactate |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity
transcriptional activation
|
VEGFA |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256592 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 8387214 |
Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding activity is induced by hypoxia in Hep3B cells, and HIF-1 binds at a site in the EPO gene enhancer that is required for hypoxic activation of transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | down-regulates
ubiquitination
|
HIF1A |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80969 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944113 |
Here we show that the product of the von hippel-lindau (vhl) tumor suppressor gene mediated ubiquitylation and proteasomal degradation of hif-1 alpha under normoxic conditions via interaction with the core of the oxygen-dependent degradation domain of hif-1 alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | up-regulates
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167187 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20670887 |
Hif1alfa is the transcription factor downstream of mtorc1 in the control of glycolytic genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209720 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19808903 |
We report a Notch signal-induced pathway that leads to transcriptional activation of HIF1-alpha gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
HIF1A | up-regulates quantity
transcriptional activation
|
EPO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256593 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 8756616 |
We demonstrate the involvement of HIF-1 in the activation of VEGF transcription. VEGF 5'-flanking sequences mediated transcriptional activation of reporter gene expression in hypoxic Hep3B cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAB2IP | down-regulates quantity by destabilization 
|
HIF1A |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27476001 |
DAB2IP destabilizes HIF1α protein to inhibit EMT in PCa cells. DAB2IP may destabilize HIF1α protein in PCa cells via an ubiquitin-proteasome system. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-oxoglutarate(2-) | up-regulates activity
chemical activation
|
HIF1A |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253138 |
|
|
|
|
| pmid |
sentence |
| 20383689 |
HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression|The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are enzymes that are functionally inactivated in hypoxia, as they use both oxygen and alpha-ketoglutarate as substrates to hydroxylate target prolyl residues. |
|
| Publications: |
1 |
| + |
HIF1A | up-regulates quantity by expression
transcriptional activation
|
CD274 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259092 |
|
|
Homo sapiens |
Lung Adenocarcinoma Cell Line, NCI-H23 Cell |
| pmid |
sentence |
| 27141364 |
STAT3 and HIF-1α cooperatively enhance PD-L1 expression in EML4-ALK-translocated pADC cells under hypoxia. Taken together, these findings suggest that EML4-ALK might increase HIF-1α expression under hypoxia by enhancing transcription and inhibiting ubiquitination of HIF-1α, resulting in the stabilization of HIF-1α, consequently contributing to HIF-1α-mediated upregulation of PD-L1 under hypoxia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
HIF1A
- 
- 