| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | HIF1A | Ser641 | DIKILIAsPSPTHIH | phosphorylation up-regulates | 18519666 | SIGNOR-178723 |
| MAPK3 | HIF1A | Ser641 | DIKILIAsPSPTHIH | phosphorylation up-regulates | 18519666 | SIGNOR-178731 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | HIF1A PSer641 | phosphorylation up-regulates → | HIF1A | 18519666 | SIGNOR-178723 |
| MAPK3 | phosphorylation up-regulates → | HIF1A PSer641 | phosphorylation up-regulates → | HIF1A | 18519666 | SIGNOR-178731 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | HIF1A | SIGNOR-178723 |
| MAPK3 | phosphorylation → up-regulates | HIF1A | SIGNOR-178731 |