Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
DUSP6	MAPK3	–		dephosphorylation down-regulates	12840032	SIGNOR-103149
DUSP6	MAPK1	–		dephosphorylation down-regulates	12840032	SIGNOR-103146
DUSP6	MAPK1	–		dephosphorylation down-regulates activity	20638106	SIGNOR-277006
DUSP6	MAPK8	–		dephosphorylation down-regulates activity	24861519	SIGNOR-277150
DUSP6	FOXO1	–		dephosphorylation up-regulates	22521266	SIGNOR-197194
DUSP6	FOXO1	Ser256	SPRRRAAsMDNNSKF	dephosphorylation up-regulates activity	22848439	SIGNOR-276983
DUSP6	MAPK7	–		dephosphorylation down-regulates activity	18280112	SIGNOR-277007
DUSP6	ERK1/2	–		dephosphorylation down-regulates	12840032	SIGNOR-269926
DUSP6	FOXO	–		dephosphorylation up-regulates	22521266	SIGNOR-252903
DUSP6	Gbeta	–		dephosphorylation down-regulates	12840032	SIGNOR-269905

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
DUSP6	dephosphorylation down-regulates ⊣	FOXO1 PSer256	dephosphorylation down-regulates ⊣	FOXO1	22848439	SIGNOR-276983

Regulator	Mechanism/Effect	Target	SIGNOR-ID
DUSP6	dephosphorylation down-regulates	MAPK3	SIGNOR-103149
DUSP6	dephosphorylation down-regulates	MAPK1	SIGNOR-103146
DUSP6	dephosphorylation → down-regulates activity	MAPK1	SIGNOR-277006
DUSP6	dephosphorylation → down-regulates activity	MAPK8	SIGNOR-277150
DUSP6	dephosphorylation → up-regulates	FOXO1	SIGNOR-197194
DUSP6	dephosphorylation → up-regulates activity	FOXO1	SIGNOR-276983
DUSP6	dephosphorylation → down-regulates activity	MAPK7	SIGNOR-277007
DUSP6	dephosphorylation down-regulates	ERK1/2	SIGNOR-269926
DUSP6	dephosphorylation → up-regulates	FOXO	SIGNOR-252903
DUSP6	dephosphorylation down-regulates	Gbeta	SIGNOR-269905