Summary

Name DUSP6
Full Name Dual specificity protein phosphatase 6
Synonyms Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3 | MKP3, PYST1
Primary ID Q16828
Links - -
Type protein
Relations 10
Function Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation DUSP6 0.35
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP6 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png DUSP6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DUSP6 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FOXO 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FOXO1 0.14
Publications: 1 Organism: Homo Sapiens