Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
Gbeta	DUSP6	–		phosphorylation down-regulates	15632084	SIGNOR-270116
MAPK3	DUSP6	Ser159	DGSCSSSsPPLPVLG	phosphorylation down-regulates	15632084	SIGNOR-132975
MAPK3	DUSP6	Ser197	SATDSDGsPLSNSQP	phosphorylation down-regulates	15632084	SIGNOR-132979
MAPK1	DUSP6	Ser197	SATDSDGsPLSNSQP	phosphorylation down-regulates quantity by destabilization	15632084	SIGNOR-132971
MAPK1	DUSP6	Ser159	DGSCSSSsPPLPVLG	phosphorylation down-regulates quantity by destabilization	15632084	SIGNOR-132967
ERK1/2	DUSP6	–		phosphorylation down-regulates	15632084	SIGNOR-270205

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK3	phosphorylation up-regulates →	DUSP6 PSer159	phosphorylation down-regulates ⊣	DUSP6	15632084	SIGNOR-132975
MAPK3	phosphorylation up-regulates →	DUSP6 PSer197	phosphorylation down-regulates ⊣	DUSP6	15632084	SIGNOR-132979
MAPK1	phosphorylation up-regulates →	DUSP6 PSer197	phosphorylation down-regulates ⊣	DUSP6	15632084	SIGNOR-132971
MAPK1	phosphorylation up-regulates →	DUSP6 PSer159	phosphorylation down-regulates ⊣	DUSP6	15632084	SIGNOR-132967

Regulator	Mechanism/Effect	Target	SIGNOR-ID
Gbeta	phosphorylation down-regulates	DUSP6	SIGNOR-270116
MAPK3	phosphorylation down-regulates	DUSP6	SIGNOR-132975
MAPK3	phosphorylation down-regulates	DUSP6	SIGNOR-132979
MAPK1	phosphorylation down-regulates quantity by destabilization	DUSP6	SIGNOR-132971
MAPK1	phosphorylation down-regulates quantity by destabilization	DUSP6	SIGNOR-132967
ERK1/2	phosphorylation down-regulates	DUSP6	SIGNOR-270205