| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | DUSP6 | Ser159 | DGSCSSSsPPLPVLG | phosphorylation down-regulates quantity by destabilization | 15632084 | SIGNOR-132967 |
| MAPK3 | DUSP6 | Ser159 | DGSCSSSsPPLPVLG | phosphorylation down-regulates | 15632084 | SIGNOR-132975 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | DUSP6 PSer159 | phosphorylation down-regulates ⊣ | DUSP6 | 15632084 | SIGNOR-132967 |
| MAPK3 | phosphorylation up-regulates → | DUSP6 PSer159 | phosphorylation down-regulates ⊣ | DUSP6 | 15632084 | SIGNOR-132975 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation![]() down-regulates quantity by destabilization | DUSP6 | SIGNOR-132967 |
| MAPK3 | phosphorylation![]() down-regulates | DUSP6 | SIGNOR-132975 |