| Name | AAK1 |
| ID | Q2M2I8 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 46-315 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AAK1 | NUMB | Thr102 | LRVVDEKtKDLIVDQ | phosphorylation unknown | 18657069 | SIGNOR-179610 |
| AAK1 | NUMB | Thr102 | LRVVDEKtKDLIVDQ | phosphorylation up-regulates | 18657069 | SIGNOR-179606 |
| AAK1 | AP2M1 | Thr156 | SQITSQVtGQIGWRR | phosphorylation up-regulates | 11877461 | SIGNOR-115657 |
| AAK1 | AP1M1 | Thr144 | QEGHKLEtGAPRPPA | phosphorylation up-regulates | 11877461 | SIGNOR-115589 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AAK1 | phosphorylation up-regulates → | NUMB PThr102 | phosphorylation down-regulates ⊣ | NUMB | 18657069 | SIGNOR-179610 |
| AAK1 | phosphorylation up-regulates → | NUMB PThr102 | phosphorylation up-regulates → | NUMB | 18657069 | SIGNOR-179606 |
| AAK1 | phosphorylation up-regulates → | AP2M1 PThr156 | phosphorylation up-regulates → | AP2M1 | 11877461 | SIGNOR-115657 |
| AAK1 | phosphorylation up-regulates → | AP1M1 PThr144 | phosphorylation up-regulates → | AP1M1 | 11877461 | SIGNOR-115589 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AAK1 | phosphorylation → unknown | NUMB | SIGNOR-179610 |
| AAK1 | phosphorylation → up-regulates | NUMB | SIGNOR-179606 |
| AAK1 | phosphorylation → up-regulates | AP2M1 | SIGNOR-115657 |
| AAK1 | phosphorylation → up-regulates | AP1M1 | SIGNOR-115589 |