Summary

Name AAK1
Full Name AP2-associated protein kinase 1
Synonyms Adaptor-associated kinase 1 | KIAA1048
Primary ID Q2M2I8
Links - -
Type protein
Relations 6
Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ STK38up-regulates activity img/direct-activation.png phosphorylation AAK1 0.276
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ AAK1 img/unknown.png phosphorylation NUMB 0.475
Publications: 1 Organism: Homo Sapiens
+ AAK1up-regulates img/direct-activation.png phosphorylation NUMB 0.475
Publications: 1 Organism: Homo Sapiens
+ AAK1up-regulates img/direct-activation.png phosphorylation AP1M1 0.2
Publications: 1 Organism: Homo Sapiens
+ AAK1up-regulates img/direct-activation.png phosphorylation AP2M1 0.778
Publications: 1 Organism: Homo Sapiens
+ AP-2 complexup-regulates activity img/direct-activation.png binding AAK1 0.635
Publications: 1 Organism: Rattus Norvegicus