Summary

Name AAK1
Full Name AP2-associated protein kinase 1
Synonyms Adaptor-associated kinase 1 | KIAA1048
Primary ID Q2M2I8
Links - -
Type protein
Relations 4
Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NUMB 0.36
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NUMB 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AP1M1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AP2M1 0.34
Publications: 1 Organism: Homo Sapiens