| Name | LRRK2 |
| ID | Q5S007 |
| Role | kinase |
| Enzymatic Domains |
Roc 1328-1511 PROSITE-ProRule
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Protein kinase 1879-2138 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LRRK2 | DNM1L | Thr595 | NWRGMLKtSKAEELL | phosphorylation up-regulates activity | 23813973 | SIGNOR-276495 |
| LRRK2 | RAB29 | Ser72 | AGQERFTsMTRLYYR | phosphorylation up-regulates activity | 29212815 | SIGNOR-279474 |
| LRRK2 | RAB29 | Thr71 | IAGQERFtSMTRLYY | phosphorylation up-regulates activity | 29212815 | SIGNOR-279475 |
| LRRK2 | RIPK2 | Ser176 | KWRMMSLsQSRSSKS | phosphorylation up-regulates activity | 27830463 | SIGNOR-278953 |
| LRRK2 | SNAPIN | Thr117 | NHSVAKEtARRRAML | phosphorylation down-regulates | 23949442 | SIGNOR-202436 |
| LRRK2 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates activity | 25446991 | SIGNOR-279531 |
| LRRK2 | MAPT | – | phosphorylation down-regulates | 22303461 | SIGNOR-195756 | |
| LRRK2 | EZR | – | phosphorylation up-regulates activity | 17447891 | SIGNOR-279202 | |
| LRRK2 | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 17447891 | SIGNOR-154498 |
| LRRK2 | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 8537411 | SIGNOR-39433 |
| LRRK2 | PRDX3 | Thr146 | SHLAWINtPRKNGGL | phosphorylation down-regulates activity | 21850687 | SIGNOR-262891 |
| LRRK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21658387 | SIGNOR-174044 |
| LRRK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 24916379 | SIGNOR-252598 |
| LRRK2 | RDX | – | phosphorylation up-regulates activity | 17447891 | SIGNOR-279203 | |
| LRRK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19576176 | SIGNOR-249690 |
| LRRK2 | NSF | Thr645 | RKLLIIGtTSRKDVL | phosphorylation up-regulates activity | 26758690 | SIGNOR-277196 |
| LRRK2 | MAP2K3 | – | phosphorylation up-regulates activity | 20067578 | SIGNOR-279057 | |
| LRRK2 | RCAN1 | – | phosphorylation up-regulates activity | 28553204 | SIGNOR-278340 | |
| LRRK2 | RAB8A | Thr72 | AGQERFRtITTAYYR | phosphorylation up-regulates activity | 32227113 | SIGNOR-260267 |
| LRRK2 | RAB5B | Thr6 | tARPNGQP | phosphorylation up-regulates activity | 25605758 | SIGNOR-276873 |
| LRRK2 | RAB10 | Thr73 | AGQERFHtITTSYYR | phosphorylation down-regulates activity | 26824392 | SIGNOR-261277 |
| LRRK2 | RPS15 | Thr136 | GRPGIGAtHSSRFIP | phosphorylation up-regulates activity | 24725412 | SIGNOR-279058 |
| LRRK2 | PTK2 | Thr474 | KFLQEALtMRQFDHP | phosphorylation down-regulates activity | 26365310 | SIGNOR-278281 |
| LRRK2 | ARHGEF7 | Thr127 | KVLSSLVtLNKVTAD | phosphorylation up-regulates | 21048939 | SIGNOR-169221 |
| LRRK2 | ARHGEF7 | Thr164 | LGSQSLHtRTSKLFQ | phosphorylation up-regulates | 21048939 | SIGNOR-169225 |
| LRRK2 | LRRK2 | Thr1491 | DYHFVNAtEESDALA | phosphorylation down-regulates | 19824698 | SIGNOR-188425 |
| LRRK2 | LRRK2 | Ser1403 | AGREEFYsTHPHFMT | phosphorylation unknown | 19824698 | SIGNOR-188429 |
| LRRK2 | LRRK2 | Thr1404 | GREEFYStHPHFMTQ | phosphorylation unknown | 19824698 | SIGNOR-188433 |
| LRRK2 | LRRK2 | Thr1410 | STHPHFMtQRALYLA | phosphorylation unknown | 19824698 | SIGNOR-188437 |
| LRRK2 | LRRK2 | Thr1967 | QQDKASLtRTLQHRI | phosphorylation up-regulates | 19824698 | SIGNOR-188417 |
| LRRK2 | LRRK2 | Thr1969 | DKASLTRtLQHRIAL | phosphorylation up-regulates | 19824698 | SIGNOR-188421 |
| LRRK2 | LRRK2 | Ser2032 | CRMGIKTsEGTPGFR | phosphorylation up-regulates | 20595391 | SIGNOR-166466 |
| LRRK2 | LRRK2 | Thr2031 | CCRMGIKtSEGTPGF | phosphorylation up-regulates | 20595391 | SIGNOR-166470 |
| LRRK2 | LRRK2 | Thr2035 | GIKTSEGtPGFRAPE | phosphorylation up-regulates | 20595391 | SIGNOR-166474 |
| LRRK2 | ARFGAP1 | – | phosphorylation down-regulates | 22363216 | SIGNOR-196267 | |
| LRRK2 | ARFGAP1 | – | phosphorylation down-regulates | 22423108 | SIGNOR-196732 | |
| LRRK2 | AP2M1 | Thr156 | SQITSQVtGQIGWRR | phosphorylation up-regulates activity | 34315807 | SIGNOR-278183 |
| LRRK2 | MAP3K5 | Thr825 | LKISDFGtSKRLAGI | phosphorylation up-regulates activity | 28888991 | SIGNOR-277251 |
| LRRK2 | SH3GL1 | – | phosphorylation down-regulates | 22998870 | SIGNOR-192068 | |
| LRRK2 | SH3GL2 | Ser75 | LSMINTMsKIRGQEK | phosphorylation down-regulates | 22998870 | SIGNOR-192072 |
| LRRK2 | SH3GL2 | – | phosphorylation down-regulates | 22998870 | SIGNOR-192075 | |
| LRRK2 | NLRC4 | Ser533 | RPLWRQEsLQSVKNT | phosphorylation up-regulates activity | 28821568 | SIGNOR-279338 |
| LRRK2 | LARS1 | Thr293 | NIFLVAAtLRPETMF | phosphorylation down-regulates activity | 30411383 | SIGNOR-277417 |
| LRRK2 | AKT | – | phosphorylation up-regulates | 21658387 | SIGNOR-244410 | |
| LRRK2 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 24916379 | SIGNOR-205115 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LRRK2 | phosphorylation up-regulates → | DNM1L PThr595 | phosphorylation up-regulates → | DNM1L | 23813973 | SIGNOR-276495 |
| LRRK2 | phosphorylation up-regulates → | RAB29 PSer72 | phosphorylation up-regulates → | RAB29 | 29212815 | SIGNOR-279474 |
| LRRK2 | phosphorylation up-regulates → | RAB29 PThr71 | phosphorylation up-regulates → | RAB29 | 29212815 | SIGNOR-279475 |
| LRRK2 | phosphorylation up-regulates → | RIPK2 PSer176 | phosphorylation up-regulates → | RIPK2 | 27830463 | SIGNOR-278953 |
| LRRK2 | phosphorylation up-regulates → | SNAPIN PThr117 | phosphorylation down-regulates ⊣ | SNAPIN | 23949442 | SIGNOR-202436 |
| LRRK2 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 25446991 | SIGNOR-279531 |
| LRRK2 | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 17447891 | SIGNOR-154498 |
| LRRK2 | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 8537411 | SIGNOR-39433 |
| LRRK2 | phosphorylation up-regulates → | PRDX3 PThr146 | phosphorylation down-regulates ⊣ | PRDX3 | 21850687 | SIGNOR-262891 |
| LRRK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21658387 | SIGNOR-174044 |
| LRRK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 24916379 | SIGNOR-252598 |
| LRRK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19576176 | SIGNOR-249690 |
| LRRK2 | phosphorylation up-regulates → | NSF PThr645 | phosphorylation up-regulates → | NSF | 26758690 | SIGNOR-277196 |
| LRRK2 | phosphorylation up-regulates → | RAB8A PThr72 | phosphorylation up-regulates → | RAB8A | 32227113 | SIGNOR-260267 |
| LRRK2 | phosphorylation up-regulates → | RAB5B PThr6 | phosphorylation up-regulates → | RAB5B | 25605758 | SIGNOR-276873 |
| LRRK2 | phosphorylation up-regulates → | RAB10 PThr73 | phosphorylation down-regulates ⊣ | RAB10 | 26824392 | SIGNOR-261277 |
| LRRK2 | phosphorylation up-regulates → | RPS15 PThr136 | phosphorylation up-regulates → | RPS15 | 24725412 | SIGNOR-279058 |
| LRRK2 | phosphorylation up-regulates → | PTK2 PThr474 | phosphorylation down-regulates ⊣ | PTK2 | 26365310 | SIGNOR-278281 |
| LRRK2 | phosphorylation up-regulates → | ARHGEF7 PThr127 | phosphorylation up-regulates → | ARHGEF7 | 21048939 | SIGNOR-169221 |
| LRRK2 | phosphorylation up-regulates → | ARHGEF7 PThr164 | phosphorylation up-regulates → | ARHGEF7 | 21048939 | SIGNOR-169225 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1491 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188425 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PSer1403 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188429 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1404 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188433 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1410 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188437 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1967 | phosphorylation up-regulates → | LRRK2 | 19824698 | SIGNOR-188417 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1969 | phosphorylation up-regulates → | LRRK2 | 19824698 | SIGNOR-188421 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PSer2032 | phosphorylation up-regulates → | LRRK2 | 20595391 | SIGNOR-166466 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr2031 | phosphorylation up-regulates → | LRRK2 | 20595391 | SIGNOR-166470 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr2035 | phosphorylation up-regulates → | LRRK2 | 20595391 | SIGNOR-166474 |
| LRRK2 | phosphorylation up-regulates → | AP2M1 PThr156 | phosphorylation up-regulates → | AP2M1 | 34315807 | SIGNOR-278183 |
| LRRK2 | phosphorylation up-regulates → | MAP3K5 PThr825 | phosphorylation up-regulates → | MAP3K5 | 28888991 | SIGNOR-277251 |
| LRRK2 | phosphorylation up-regulates → | SH3GL2 PSer75 | phosphorylation down-regulates ⊣ | SH3GL2 | 22998870 | SIGNOR-192072 |
| LRRK2 | phosphorylation up-regulates → | NLRC4 PSer533 | phosphorylation up-regulates → | NLRC4 | 28821568 | SIGNOR-279338 |
| LRRK2 | phosphorylation up-regulates → | LARS1 PThr293 | phosphorylation down-regulates ⊣ | LARS1 | 30411383 | SIGNOR-277417 |
| LRRK2 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 24916379 | SIGNOR-205115 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LRRK2 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-276495 |
| LRRK2 | phosphorylation → up-regulates activity | RAB29 | SIGNOR-279474 |
| LRRK2 | phosphorylation → up-regulates activity | RAB29 | SIGNOR-279475 |
| LRRK2 | phosphorylation → up-regulates activity | RIPK2 | SIGNOR-278953 |
| LRRK2 | phosphorylation down-regulates | SNAPIN | SIGNOR-202436 |
| LRRK2 | phosphorylation → up-regulates activity | BCL2 | SIGNOR-279531 |
| LRRK2 | phosphorylation down-regulates | MAPT | SIGNOR-195756 |
| LRRK2 | phosphorylation → up-regulates activity | EZR | SIGNOR-279202 |
| LRRK2 | phosphorylation → up-regulates activity | MSN | SIGNOR-154498 |
| LRRK2 | phosphorylation → up-regulates activity | MSN | SIGNOR-39433 |
| LRRK2 | phosphorylation → down-regulates activity | PRDX3 | SIGNOR-262891 |
| LRRK2 | phosphorylation → up-regulates | AKT1 | SIGNOR-174044 |
| LRRK2 | phosphorylation → up-regulates | AKT1 | SIGNOR-252598 |
| LRRK2 | phosphorylation → up-regulates activity | RDX | SIGNOR-279203 |
| LRRK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-249690 |
| LRRK2 | phosphorylation → up-regulates activity | NSF | SIGNOR-277196 |
| LRRK2 | phosphorylation → up-regulates activity | MAP2K3 | SIGNOR-279057 |
| LRRK2 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-278340 |
| LRRK2 | phosphorylation → up-regulates activity | RAB8A | SIGNOR-260267 |
| LRRK2 | phosphorylation → up-regulates activity | RAB5B | SIGNOR-276873 |
| LRRK2 | phosphorylation → down-regulates activity | RAB10 | SIGNOR-261277 |
| LRRK2 | phosphorylation → up-regulates activity | RPS15 | SIGNOR-279058 |
| LRRK2 | phosphorylation → down-regulates activity | PTK2 | SIGNOR-278281 |
| LRRK2 | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-169221 |
| LRRK2 | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-169225 |
| LRRK2 | phosphorylation down-regulates | LRRK2 | SIGNOR-188425 |
| LRRK2 | phosphorylation → unknown | LRRK2 | SIGNOR-188429 |
| LRRK2 | phosphorylation → unknown | LRRK2 | SIGNOR-188433 |
| LRRK2 | phosphorylation → unknown | LRRK2 | SIGNOR-188437 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-188417 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-188421 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-166466 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-166470 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-166474 |
| LRRK2 | phosphorylation down-regulates | ARFGAP1 | SIGNOR-196267 |
| LRRK2 | phosphorylation down-regulates | ARFGAP1 | SIGNOR-196732 |
| LRRK2 | phosphorylation → up-regulates activity | AP2M1 | SIGNOR-278183 |
| LRRK2 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-277251 |
| LRRK2 | phosphorylation down-regulates | SH3GL1 | SIGNOR-192068 |
| LRRK2 | phosphorylation down-regulates | SH3GL2 | SIGNOR-192072 |
| LRRK2 | phosphorylation down-regulates | SH3GL2 | SIGNOR-192075 |
| LRRK2 | phosphorylation → up-regulates activity | NLRC4 | SIGNOR-279338 |
| LRRK2 | phosphorylation → down-regulates activity | LARS1 | SIGNOR-277417 |
| LRRK2 | phosphorylation → up-regulates | AKT | SIGNOR-244410 |
| LRRK2 | phosphorylation → up-regulates | AKT | SIGNOR-205115 |