Summary

Name LRRK2
Full Name Leucine-rich repeat serine/threonine-protein kinase 2
Synonyms Dardarin | PARK8
Primary ID Q5S007
Links - -
Type protein
Relations 30
Pathways Parkinson disease
Function Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SNCA 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ img/unknown.png phosphorylation LRRK2 0.14
Publications: 3 Organism: Homo Sapiens
Pathways:Parkinson disease
+ down-regulates activity img/direct_inhibition.png phosphorylation LRRK2 0.22
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LRRK2 0.2
Publications: 5 Organism: Homo Sapiens
Pathways:Parkinson disease
+ up-regulates img/direct-activation.png phosphorylation AKT 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:Parkinson disease
+ down-regulates img/direct_inhibition.png phosphorylation SH3GL2 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SNAPIN 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation ARHGEF7 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LRRK2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ up-regulates img/direct-activation.png phosphorylation MSN 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding LRRK2 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRRK2 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation SH3GL1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARFGAP1 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding DVL3 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Autophagy 0.36
Publications: 1 Organism: Homo Sapiens