| Name | LRRK2 |
| ID | Q5S007 |
| Role | substrate |
| Enzymatic Domains |
Roc 1328-1511 PROSITE-ProRule
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Protein kinase 1879-2138 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LRRK2 | LRRK2 | Ser1403 | AGREEFYsTHPHFMT | phosphorylation unknown | 19824698 | SIGNOR-188429 |
| LRRK2 | LRRK2 | Thr1969 | DKASLTRtLQHRIAL | phosphorylation up-regulates | 19824698 | SIGNOR-188421 |
| LRRK2 | LRRK2 | Ser2032 | CRMGIKTsEGTPGFR | phosphorylation up-regulates | 20595391 | SIGNOR-166466 |
| LRRK2 | LRRK2 | Thr2031 | CCRMGIKtSEGTPGF | phosphorylation up-regulates | 20595391 | SIGNOR-166470 |
| LRRK2 | LRRK2 | Thr1404 | GREEFYStHPHFMTQ | phosphorylation unknown | 19824698 | SIGNOR-188433 |
| LRRK2 | LRRK2 | Thr2035 | GIKTSEGtPGFRAPE | phosphorylation up-regulates | 20595391 | SIGNOR-166474 |
| LRRK2 | LRRK2 | Thr1410 | STHPHFMtQRALYLA | phosphorylation unknown | 19824698 | SIGNOR-188437 |
| LRRK2 | LRRK2 | Thr1967 | QQDKASLtRTLQHRI | phosphorylation up-regulates | 19824698 | SIGNOR-188417 |
| PRKACA | LRRK2 | Ser1444 | NIKARASsSPVILVG | phosphorylation down-regulates activity | 24351927 | SIGNOR-237444 |
| LRRK2 | LRRK2 | Thr1491 | DYHFVNAtEESDALA | phosphorylation down-regulates | 19824698 | SIGNOR-188425 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LRRK2 | phosphorylation up-regulates → | LRRK2 PSer1403 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188429 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1969 | phosphorylation up-regulates → | LRRK2 | 19824698 | SIGNOR-188421 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PSer2032 | phosphorylation up-regulates → | LRRK2 | 20595391 | SIGNOR-166466 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr2031 | phosphorylation up-regulates → | LRRK2 | 20595391 | SIGNOR-166470 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1404 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188433 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr2035 | phosphorylation up-regulates → | LRRK2 | 20595391 | SIGNOR-166474 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1410 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188437 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1967 | phosphorylation up-regulates → | LRRK2 | 19824698 | SIGNOR-188417 |
| PRKACA | phosphorylation up-regulates → | LRRK2 PSer1444 | phosphorylation down-regulates ⊣ | LRRK2 | 24351927 | SIGNOR-237444 |
| LRRK2 | phosphorylation up-regulates → | LRRK2 PThr1491 | phosphorylation down-regulates ⊣ | LRRK2 | 19824698 | SIGNOR-188425 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LRRK2 | phosphorylation → unknown | LRRK2 | SIGNOR-188429 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-188421 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-166466 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-166470 |
| LRRK2 | phosphorylation → unknown | LRRK2 | SIGNOR-188433 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-166474 |
| LRRK2 | phosphorylation → unknown | LRRK2 | SIGNOR-188437 |
| LRRK2 | phosphorylation → up-regulates | LRRK2 | SIGNOR-188417 |
| PRKACA | phosphorylation → down-regulates activity | LRRK2 | SIGNOR-237444 |
| LRRK2 | phosphorylation down-regulates | LRRK2 | SIGNOR-188425 |