| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | LRRK2 | Ser1444 | NIKARASsSPVILVG | phosphorylation down-regulates activity | 24351927 | SIGNOR-237444 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | LRRK2 PSer1444 | phosphorylation down-regulates ⊣ | LRRK2 | 24351927 | SIGNOR-237444 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | LRRK2 | SIGNOR-237444 |