| Name | MARK2 |
| ID | Q7KZI7 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 53-304 PROSITE-ProRule
UBA 323-362 PROSITE-ProRule
KA1 739-788 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK2 | MAPT | Ser355 | EADLPEPsEKQPAAA | phosphorylation down-regulates activity | 10090741 | SIGNOR-275436 |
| MARK2 | MAPT | – | phosphorylation down-regulates quantity | 36048712 | SIGNOR-280038 | |
| MARK2 | MAPT | Ser267 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275435 |
| MARK2 | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275437 |
| MARK2 | UTRN | Ser1258 | TLEERMKsTEVLPEK | phosphorylation up-regulates | 19945424 | SIGNOR-161915 |
| MARK2 | TNK1 | Ser502 | RMKGISRsLESVLSL | phosphorylation down-regulates activity | 34504101 | SIGNOR-273867 |
| MARK2 | RAB11FIP1 | Ser234 | QKTPLSQsMSVLPTS | phosphorylation up-regulates quantity | 28396819 | SIGNOR-273676 |
| MARK2 | RAB11FIP2 | Ser227 | QRLSSAHsMSDLSGS | phosphorylation up-regulates | 16775013 | SIGNOR-147118 |
| MARK2 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation down-regulates activity | 22206009 | SIGNOR-279343 |
| MARK2 | PARD3 | Ser873 | VDDQKAGsPSRDVGP | phosphorylation up-regulates | 22883624 | SIGNOR-198742 |
| MARK2 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 16980613 | SIGNOR-149583 |
| MARK2 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 22072711 | SIGNOR-177096 |
| MARK2 | ARHGEF2 | Ser960 | SRLSPPHsPRDFTRM | phosphorylation down-regulates | 22072711 | SIGNOR-177100 |
| MARK2 | PINK1 | Thr313 | EGLGHGRtLFLVMKN | phosphorylation up-regulates activity | 22238344 | SIGNOR-276401 |
| MARK2 | PINK1 | – | phosphorylation up-regulates activity | 22238344 | SIGNOR-278975 | |
| MARK2 | KIF13B | Ser1381 | KLSRRSIsSPNVNRL | phosphorylation down-regulates activity | 20194617 | SIGNOR-262955 |
| MARK2 | KIF13B | Ser1410 | SNKGRWEsQQDVSQT | phosphorylation down-regulates activity | 20194617 | SIGNOR-262956 |
| MARK2 | BAIAP2 | Ser366 | KTLPRSSsMAAGLER | phosphorylation down-regulates activity | 21282462 | SIGNOR-278411 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK2 | phosphorylation up-regulates → | MAPT PSer355 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275436 |
| MARK2 | phosphorylation up-regulates → | MAPT PSer267 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275435 |
| MARK2 | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275437 |
| MARK2 | phosphorylation up-regulates → | UTRN PSer1258 | phosphorylation up-regulates → | UTRN | 19945424 | SIGNOR-161915 |
| MARK2 | phosphorylation up-regulates → | TNK1 PSer502 | phosphorylation down-regulates ⊣ | TNK1 | 34504101 | SIGNOR-273867 |
| MARK2 | phosphorylation up-regulates → | RAB11FIP1 PSer234 | phosphorylation up-regulates → | RAB11FIP1 | 28396819 | SIGNOR-273676 |
| MARK2 | phosphorylation up-regulates → | RAB11FIP2 PSer227 | phosphorylation up-regulates → | RAB11FIP2 | 16775013 | SIGNOR-147118 |
| MARK2 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 22206009 | SIGNOR-279343 |
| MARK2 | phosphorylation up-regulates → | PARD3 PSer873 | phosphorylation up-regulates → | PARD3 | 22883624 | SIGNOR-198742 |
| MARK2 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 16980613 | SIGNOR-149583 |
| MARK2 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 22072711 | SIGNOR-177096 |
| MARK2 | phosphorylation up-regulates → | ARHGEF2 PSer960 | phosphorylation down-regulates ⊣ | ARHGEF2 | 22072711 | SIGNOR-177100 |
| MARK2 | phosphorylation up-regulates → | PINK1 PThr313 | phosphorylation up-regulates → | PINK1 | 22238344 | SIGNOR-276401 |
| MARK2 | phosphorylation up-regulates → | KIF13B PSer1381 | phosphorylation down-regulates ⊣ | KIF13B | 20194617 | SIGNOR-262955 |
| MARK2 | phosphorylation up-regulates → | KIF13B PSer1410 | phosphorylation down-regulates ⊣ | KIF13B | 20194617 | SIGNOR-262956 |
| MARK2 | phosphorylation up-regulates → | BAIAP2 PSer366 | phosphorylation down-regulates ⊣ | BAIAP2 | 21282462 | SIGNOR-278411 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MARK2 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275436 |
| MARK2 | phosphorylation → down-regulates quantity | MAPT | SIGNOR-280038 |
| MARK2 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275435 |
| MARK2 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275437 |
| MARK2 | phosphorylation → up-regulates | UTRN | SIGNOR-161915 |
| MARK2 | phosphorylation → down-regulates activity | TNK1 | SIGNOR-273867 |
| MARK2 | phosphorylation → up-regulates quantity | RAB11FIP1 | SIGNOR-273676 |
| MARK2 | phosphorylation → up-regulates | RAB11FIP2 | SIGNOR-147118 |
| MARK2 | phosphorylation → down-regulates activity | KSR1 | SIGNOR-279343 |
| MARK2 | phosphorylation → up-regulates | PARD3 | SIGNOR-198742 |
| MARK2 | phosphorylation down-regulates | HDAC7 | SIGNOR-149583 |
| MARK2 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-177096 |
| MARK2 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-177100 |
| MARK2 | phosphorylation → up-regulates activity | PINK1 | SIGNOR-276401 |
| MARK2 | phosphorylation → up-regulates activity | PINK1 | SIGNOR-278975 |
| MARK2 | phosphorylation → down-regulates activity | KIF13B | SIGNOR-262955 |
| MARK2 | phosphorylation → down-regulates activity | KIF13B | SIGNOR-262956 |
| MARK2 | phosphorylation → down-regulates activity | BAIAP2 | SIGNOR-278411 |