Summary

Name MARK2
Full Name Serine/threonine-protein kinase MARK2
Synonyms ELKL motif kinase 1, EMK-1, MAP/microtubule affinity-regulating kinase 2, PAR1 homolog, PAR1 homolog b, Par-1b, Par1b | EMK1
Primary ID Q7KZI7
Links - -
Type protein
Relations 9
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation UTRN 0.74
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation HDAC7 0.95
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAB11FIP2 0.80
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation PARD3 0.97
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGEF2 0.92
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MARK2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MARK2 0.53
Publications: 1 Organism: Homo Sapiens