| Name | MARK2 |
| ID | Q7KZI7 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 53-304 PROSITE-ProRule
UBA 323-362 PROSITE-ProRule
KA1 739-788 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | MARK2 | Thr596 | RGVSSRStFHAGQLR | phosphorylation down-regulates | 15084291 | SIGNOR-124217 |
| STK11 | MARK2 | – | phosphorylation up-regulates | 17573348 | SIGNOR-156126 | |
| GSK3B | MARK2 | Ser212 | KLDTFCGsPPYAAPE | phosphorylation down-regulates activity | 18424437 | SIGNOR-276163 |
| TAOK1 | MARK2 | Thr208 | TFGNKLDtFCGSPPY | phosphorylation up-regulates activity | 18424437 | SIGNOR-276164 |
| PRKACA | MARK2 | Ser409 | NPKQRRFsDQAAGPA | phosphorylation down-regulates activity | 25512381 | SIGNOR-276870 |
| STK11 | MARK2 | Thr208 | TFGNKLDtFCGSPPY | phosphorylation up-regulates activity | 18424437 | SIGNOR-276165 |
| STK11 | MARK2 | Thr208 | TFGNKLDtFCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122628 |
| GSK3B | MARK2 | Ser212 | KLDTFCGsPPYAAPE | phosphorylation up-regulates activity | 16257959 | SIGNOR-279413 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | MARK2 PThr596 | phosphorylation down-regulates ⊣ | MARK2 | 15084291 | SIGNOR-124217 |
| GSK3B | phosphorylation up-regulates → | MARK2 PSer212 | phosphorylation down-regulates ⊣ | MARK2 | 18424437 | SIGNOR-276163 |
| TAOK1 | phosphorylation up-regulates → | MARK2 PThr208 | phosphorylation up-regulates → | MARK2 | 18424437 | SIGNOR-276164 |
| PRKACA | phosphorylation up-regulates → | MARK2 PSer409 | phosphorylation down-regulates ⊣ | MARK2 | 25512381 | SIGNOR-276870 |
| STK11 | phosphorylation up-regulates → | MARK2 PThr208 | phosphorylation up-regulates → | MARK2 | 18424437 | SIGNOR-276165 |
| STK11 | phosphorylation up-regulates → | MARK2 PThr208 | phosphorylation up-regulates → | MARK2 | 14976552 | SIGNOR-122628 |
| GSK3B | phosphorylation up-regulates → | MARK2 PSer212 | phosphorylation up-regulates → | MARK2 | 16257959 | SIGNOR-279413 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation down-regulates | MARK2 | SIGNOR-124217 |
| STK11 | phosphorylation → up-regulates | MARK2 | SIGNOR-156126 |
| GSK3B | phosphorylation → down-regulates activity | MARK2 | SIGNOR-276163 |
| TAOK1 | phosphorylation → up-regulates activity | MARK2 | SIGNOR-276164 |
| PRKACA | phosphorylation → down-regulates activity | MARK2 | SIGNOR-276870 |
| STK11 | phosphorylation → up-regulates activity | MARK2 | SIGNOR-276165 |
| STK11 | phosphorylation → up-regulates | MARK2 | SIGNOR-122628 |
| GSK3B | phosphorylation → up-regulates activity | MARK2 | SIGNOR-279413 |