| Name | NOXA1 |
| ID | Q86UR1 |
| Role | substrate |
| Enzymatic Domains |
PB1 315-395 PROSITE-ProRule
SH3 399-458 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | NOXA1 | Ser172 | DQVQRRGsLPPRQVP | phosphorylation down-regulates activity | 20943948 | SIGNOR-264712 |
| MAPK1 | NOXA1 | Ser282 | VGKQAPLsPGLPAMG | phosphorylation down-regulates | 20110267 | SIGNOR-163659 |
| PKA | NOXA1 | Ser461 | VPAGPRMsGAPGRLP | phosphorylation down-regulates activity | 20943948 | SIGNOR-264713 |
| PRKACA | NOXA1 | Ser172 | DQVQRRGsLPPRQVP | phosphorylation down-regulates | 20110267 | SIGNOR-163663 |
| MAPK3 | NOXA1 | Ser282 | VGKQAPLsPGLPAMG | phosphorylation down-regulates | 20230789 | SIGNOR-164231 |
| Gbeta | NOXA1 | – | phosphorylation down-regulates | 20230789 | SIGNOR-270114 | |
| PRKCA | NOXA1 | Ser172 | DQVQRRGsLPPRQVP | phosphorylation down-regulates | 20110267 | SIGNOR-163667 |
| SRC | NOXA1 | Tyr110 | RGHAAIDyTQLGLRF | phosphorylation up-regulates | 20943948 | SIGNOR-168545 |
| ERK1/2 | NOXA1 | – | phosphorylation down-regulates | 20230789 | SIGNOR-270203 | |
| MAPK1 | NOXA1 | Ser282 | VGKQAPLsPGLPAMG | phosphorylation down-regulates | 20230789 | SIGNOR-164227 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | NOXA1 PSer172 | phosphorylation down-regulates ⊣ | NOXA1 | 20943948 | SIGNOR-264712 |
| MAPK1 | phosphorylation up-regulates → | NOXA1 PSer282 | phosphorylation down-regulates ⊣ | NOXA1 | 20110267 | SIGNOR-163659 |
| PKA | phosphorylation up-regulates → | NOXA1 PSer461 | phosphorylation down-regulates ⊣ | NOXA1 | 20943948 | SIGNOR-264713 |
| PRKACA | phosphorylation up-regulates → | NOXA1 PSer172 | phosphorylation down-regulates ⊣ | NOXA1 | 20110267 | SIGNOR-163663 |
| MAPK3 | phosphorylation up-regulates → | NOXA1 PSer282 | phosphorylation down-regulates ⊣ | NOXA1 | 20230789 | SIGNOR-164231 |
| PRKCA | phosphorylation up-regulates → | NOXA1 PSer172 | phosphorylation down-regulates ⊣ | NOXA1 | 20110267 | SIGNOR-163667 |
| SRC | phosphorylation up-regulates → | NOXA1 PTyr110 | phosphorylation up-regulates → | NOXA1 | 20943948 | SIGNOR-168545 |
| MAPK1 | phosphorylation up-regulates → | NOXA1 PSer282 | phosphorylation down-regulates ⊣ | NOXA1 | 20230789 | SIGNOR-164227 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | NOXA1 | SIGNOR-264712 |
| MAPK1 | phosphorylation down-regulates | NOXA1 | SIGNOR-163659 |
| PKA | phosphorylation → down-regulates activity | NOXA1 | SIGNOR-264713 |
| PRKACA | phosphorylation down-regulates | NOXA1 | SIGNOR-163663 |
| MAPK3 | phosphorylation down-regulates | NOXA1 | SIGNOR-164231 |
| Gbeta | phosphorylation down-regulates | NOXA1 | SIGNOR-270114 |
| PRKCA | phosphorylation down-regulates | NOXA1 | SIGNOR-163667 |
| SRC | phosphorylation → up-regulates | NOXA1 | SIGNOR-168545 |
| ERK1/2 | phosphorylation down-regulates | NOXA1 | SIGNOR-270203 |
| MAPK1 | phosphorylation down-regulates | NOXA1 | SIGNOR-164227 |