| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | STING1 | Ser358 | VPSTSTMsQEPELLI | dephosphorylation down-regulates activity | 25815785 | SIGNOR-276958 |
| TBK1 | STING1 | Ser358 | VPSTSTMsQEPELLI | phosphorylation up-regulates activity | 18818105 | SIGNOR-263136 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | STING1 PSer358 | dephosphorylation up-regulates → | STING1 | 25815785 | SIGNOR-276958 |
| TBK1 | phosphorylation up-regulates → | STING1 PSer358 | phosphorylation up-regulates → | STING1 | 18818105 | SIGNOR-263136 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation → down-regulates activity | STING1 | SIGNOR-276958 |
| TBK1 | phosphorylation → up-regulates activity | STING1 | SIGNOR-263136 |
