3.0
Summary
| Name |  STING1View Modifications |
| Full Name | Stimulator of interferon genes protein |
| Synonyms | hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173 | ERIS, MITA, STING |
| Primary ID | Q86WV6 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Pathways | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA |
| Function | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010, PubMed:30842659). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RNF5 | down-regulates quantity by destabilization 
ubiquitination
|
STING1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TBK1 | up-regulates activity 
phosphorylation
|
STING1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA | |||
| + | USP21 | down-regulates activity
deubiquitination
|
STING1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAVS | up-regulates activity
binding
|
STING1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA | |||
| + | DDX41 | up-regulates activity
binding
|
STING1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | STING1 | up-regulates activity
binding
|
TBK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA | |||
| + | Papain-like proteinase | down-regulates activity
binding
|
STING1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA | |||