| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CILK1 | RPTOR | Thr908 | LPSGRPGtTGPAGAQ | phosphorylation up-regulates | 22356909 | SIGNOR-196198 |
| PRKAA2 | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation down-regulates | 18439900 | SIGNOR-263045 |
| NLK | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation down-regulates activity | 26588989 | SIGNOR-273908 |
| DAPK2 | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation down-regulates activity | 25361081 | SIGNOR-278243 |
| Gbeta | RPTOR | – | phosphorylation up-regulates activity | 21071439 | SIGNOR-270032 | |
| PRKAB1 | RPTOR | – | phosphorylation down-regulates | 21460634 | SIGNOR-173041 | |
| RPS6KA1 | RPTOR | Ser719 | PCTPRLRsVSSYGNI | phosphorylation up-regulates | 18722121 | SIGNOR-180458 |
| MAPK1 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation unknown | 21071439 | SIGNOR-169522 |
| RPS6KA1 | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation up-regulates | 18722121 | SIGNOR-180466 |
| RPS6K | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation up-regulates | 18722121 | SIGNOR-252774 |
| MTOR | RPTOR | Ser859 | DTSSLTQsAPASPTN | phosphorylation up-regulates activity | 19346248 | SIGNOR-184959 |
| MAPK3 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-169534 |
| PRKAA1 | RPTOR | Ser792 | DKMRRASsYSSLNSL | phosphorylation down-regulates activity | 18439900 | SIGNOR-161375 |
| RPS6K | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation up-regulates | 18722121 | SIGNOR-252773 |
| PRKAA2 | RPTOR | Ser792 | LTQSAPAsPTNKGVH | phosphorylation down-regulates activity | 18439900 | SIGNOR-163463 |
| MAPK3 | RPTOR | Ser696 | EKNYALPsPATTEGG | phosphorylation up-regulates activity | 21071439 | SIGNOR-169526 |
| PRKAA1 | RPTOR | – | phosphorylation down-regulates activity | 21460634 | SIGNOR-173035 | |
| MAPK1 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-188916 |
| RPS6KA1 | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation up-regulates | 18722121 | SIGNOR-180462 |
| RPS6K | RPTOR | Ser719 | PCTPRLRsVSSYGNI | phosphorylation up-regulates | 18722121 | SIGNOR-252772 |
| AMPK | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation down-regulates | 18439900 | SIGNOR-263046 |
| CDK1 | RPTOR | Ser696 | EKNYALPsPATTEGG | phosphorylation unknown | 20169205 | SIGNOR-163849 |
| MAPK11 | RPTOR | Ser771 | SASSTLGsPENEEHI | phosphorylation unknown | 21757713 | SIGNOR-174870 |
| MAPK1 | RPTOR | Ser696 | EKNYALPsPATTEGG | phosphorylation unknown | 21071439 | SIGNOR-169514 |
| MAPK11 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation unknown | 21757713 | SIGNOR-174874 |
| ULK1 | RPTOR | Ser792 | DKMRRASsYSSLNSL | phosphorylation down-regulates activity | 25761126 | SIGNOR-278461 |
| MTOR | RPTOR | Ser855 | QRVLDTSsLTQSAPA | phosphorylation up-regulates activity | 19864431 | SIGNOR-174882 |
| CDK1 | RPTOR | Thr706 | TTEGGSLtPVRDSPC | phosphorylation unknown | 20169205 | SIGNOR-163853 |
| ERK1/2 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-174878 |
| MTOR | RPTOR | Ser859 | DTSSLTQsAPASPTN | phosphorylation up-regulates activity | 19864431 | SIGNOR-188920 |
| AMPK | RPTOR | Ser792 | LTQSAPAsPTNKGVH | phosphorylation down-regulates | 18439900 | SIGNOR-263044 |
| MTOR | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 19864431 | SIGNOR-188924 |
| MAPK1 | RPTOR | Ser8 | MESEMLQsPLLGLGE | phosphorylation unknown | 21071439 | SIGNOR-169518 |
| MAPK3 | RPTOR | Ser8 | MESEMLQsPLLGLGE | phosphorylation up-regulates activity | 21071439 | SIGNOR-169530 |
| PLK1 | RPTOR | – | phosphorylation up-regulates activity | 28102733 | SIGNOR-279346 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CILK1 | phosphorylation up-regulates → | RPTOR PThr908 | phosphorylation up-regulates → | RPTOR | 22356909 | SIGNOR-196198 |
| PRKAA2 | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-263045 |
| NLK | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 26588989 | SIGNOR-273908 |
| DAPK2 | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation down-regulates ⊣ | RPTOR | 25361081 | SIGNOR-278243 |
| RPS6KA1 | phosphorylation up-regulates → | RPTOR PSer719 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-180458 |
| MAPK1 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 21071439 | SIGNOR-169522 |
| RPS6KA1 | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-180466 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252774 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer859 | phosphorylation up-regulates → | RPTOR | 19346248 | SIGNOR-184959 |
| MAPK3 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-169534 |
| PRKAA1 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-161375 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252773 |
| PRKAA2 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-163463 |
| MAPK3 | phosphorylation up-regulates → | RPTOR PSer696 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-169526 |
| MAPK1 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-188916 |
| RPS6KA1 | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-180462 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer719 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252772 |
| AMPK | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-263046 |
| CDK1 | phosphorylation up-regulates → | RPTOR PSer696 | phosphorylation down-regulates ⊣ | RPTOR | 20169205 | SIGNOR-163849 |
| MAPK11 | phosphorylation up-regulates → | RPTOR PSer771 | phosphorylation down-regulates ⊣ | RPTOR | 21757713 | SIGNOR-174870 |
| MAPK1 | phosphorylation up-regulates → | RPTOR PSer696 | phosphorylation down-regulates ⊣ | RPTOR | 21071439 | SIGNOR-169514 |
| MAPK11 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 21757713 | SIGNOR-174874 |
| ULK1 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 25761126 | SIGNOR-278461 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer855 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-174882 |
| CDK1 | phosphorylation up-regulates → | RPTOR PThr706 | phosphorylation down-regulates ⊣ | RPTOR | 20169205 | SIGNOR-163853 |
| ERK1/2 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-174878 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer859 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-188920 |
| AMPK | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-263044 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-188924 |
| MAPK1 | phosphorylation up-regulates → | RPTOR PSer8 | phosphorylation down-regulates ⊣ | RPTOR | 21071439 | SIGNOR-169518 |
| MAPK3 | phosphorylation up-regulates → | RPTOR PSer8 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-169530 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CILK1 | phosphorylation → up-regulates | RPTOR | SIGNOR-196198 |
| PRKAA2 | phosphorylation down-regulates | RPTOR | SIGNOR-263045 |
| NLK | phosphorylation → down-regulates activity | RPTOR | SIGNOR-273908 |
| DAPK2 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-278243 |
| Gbeta | phosphorylation → up-regulates activity | RPTOR | SIGNOR-270032 |
| PRKAB1 | phosphorylation down-regulates | RPTOR | SIGNOR-173041 |
| RPS6KA1 | phosphorylation → up-regulates | RPTOR | SIGNOR-180458 |
| MAPK1 | phosphorylation → unknown | RPTOR | SIGNOR-169522 |
| RPS6KA1 | phosphorylation → up-regulates | RPTOR | SIGNOR-180466 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252774 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-184959 |
| MAPK3 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-169534 |
| PRKAA1 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-161375 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252773 |
| PRKAA2 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-163463 |
| MAPK3 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-169526 |
| PRKAA1 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-173035 |
| MAPK1 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188916 |
| RPS6KA1 | phosphorylation → up-regulates | RPTOR | SIGNOR-180462 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252772 |
| AMPK | phosphorylation down-regulates | RPTOR | SIGNOR-263046 |
| CDK1 | phosphorylation → unknown | RPTOR | SIGNOR-163849 |
| MAPK11 | phosphorylation → unknown | RPTOR | SIGNOR-174870 |
| MAPK1 | phosphorylation → unknown | RPTOR | SIGNOR-169514 |
| MAPK11 | phosphorylation → unknown | RPTOR | SIGNOR-174874 |
| ULK1 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-278461 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-174882 |
| CDK1 | phosphorylation → unknown | RPTOR | SIGNOR-163853 |
| ERK1/2 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-174878 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188920 |
| AMPK | phosphorylation down-regulates | RPTOR | SIGNOR-263044 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188924 |
| MAPK1 | phosphorylation → unknown | RPTOR | SIGNOR-169518 |
| MAPK3 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-169530 |
| PLK1 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-279346 |
