Summary

Name RPTOR
Full Name Regulatory-associated protein of mTOR
Synonyms Raptor, p150 target of rapamycin (TOR)-scaffold protein | KIAA1303, RAPTOR
Primary ID Q8N122
Links - -
Type protein
Relations 30
Pathways MTOR Signaling
Function Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.23
Publications: 5 Organism: Homo Sapiens, Mus Musculus
+ img/unknown.png phosphorylation RPTOR 0.14
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPTOR 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPTOR 0.22
Publications: 3 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation RPTOR 0.14
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPTOR 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RPTOR 0.51
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.7
Publications: 4 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation RPTOR 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPTOR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RPTOR 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RPTOR 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RPTOR 0.28
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding mTORC1 0.14
Publications: 1 Organism: Homo Sapiens