| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | RPTOR | Ser792 | DKMRRASsYSSLNSL | phosphorylation down-regulates activity | 25761126 | SIGNOR-278461 |
| AMPK | RPTOR | Ser792 | LTQSAPAsPTNKGVH | phosphorylation down-regulates | 18439900 | SIGNOR-263044 |
| PRKAA1 | RPTOR | Ser792 | DKMRRASsYSSLNSL | phosphorylation down-regulates activity | 18439900 | SIGNOR-161375 |
| PRKAA2 | RPTOR | Ser792 | LTQSAPAsPTNKGVH | phosphorylation down-regulates activity | 18439900 | SIGNOR-163463 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 25761126 | SIGNOR-278461 |
| AMPK | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-263044 |
| PRKAA1 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-161375 |
| PRKAA2 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-163463 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ULK1 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-278461 |
| AMPK | phosphorylation down-regulates | RPTOR | SIGNOR-263044 |
| PRKAA1 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-161375 |
| PRKAA2 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-163463 |
