| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-188916 |
| MTOR | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 19864431 | SIGNOR-188924 |
| ERK1/2 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-174878 |
| NLK | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation down-regulates activity | 26588989 | SIGNOR-273908 |
| MAPK3 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-169534 |
| MAPK1 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation unknown | 21071439 | SIGNOR-169522 |
| MAPK11 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation unknown | 21757713 | SIGNOR-174874 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-188916 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-188924 |
| ERK1/2 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-174878 |
| NLK | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 26588989 | SIGNOR-273908 |
| MAPK3 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-169534 |
| MAPK1 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 21071439 | SIGNOR-169522 |
| MAPK11 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 21757713 | SIGNOR-174874 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188916 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188924 |
| ERK1/2 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-174878 |
| NLK | phosphorylation → down-regulates activity | RPTOR | SIGNOR-273908 |
| MAPK3 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-169534 |
| MAPK1 | phosphorylation → unknown | RPTOR | SIGNOR-169522 |
| MAPK11 | phosphorylation → unknown | RPTOR | SIGNOR-174874 |
