| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DAPK2 | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation down-regulates activity | 25361081 | SIGNOR-278243 |
| RPS6K | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation up-regulates | 18722121 | SIGNOR-252774 |
| RPS6KA1 | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation up-regulates | 18722121 | SIGNOR-180462 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DAPK2 | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation down-regulates ⊣ | RPTOR | 25361081 | SIGNOR-278243 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252774 |
| RPS6KA1 | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-180462 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DAPK2 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-278243 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252774 |
| RPS6KA1 | phosphorylation → up-regulates | RPTOR | SIGNOR-180462 |
