| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation down-regulates | 18439900 | SIGNOR-263045 |
| RPS6KA1 | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation up-regulates | 18722121 | SIGNOR-180466 |
| RPS6K | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation up-regulates | 18722121 | SIGNOR-252773 |
| AMPK | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation down-regulates | 18439900 | SIGNOR-263046 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-263045 |
| RPS6KA1 | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-180466 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252773 |
| AMPK | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation down-regulates ⊣ | RPTOR | 18439900 | SIGNOR-263046 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA2 | phosphorylation down-regulates | RPTOR | SIGNOR-263045 |
| RPS6KA1 | phosphorylation → up-regulates | RPTOR | SIGNOR-180466 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252773 |
| AMPK | phosphorylation down-regulates | RPTOR | SIGNOR-263046 |
