Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK3	RPTOR	Ser696 View in OncoXplorer	EKNYALPsPATTEGG	phosphorylation up-regulates activity	21071439	SIGNOR-169526
CDK1	RPTOR	Ser696 View in OncoXplorer	EKNYALPsPATTEGG	phosphorylation unknown	20169205	SIGNOR-163849
MAPK1	RPTOR	Ser696 View in OncoXplorer	EKNYALPsPATTEGG	phosphorylation unknown	21071439	SIGNOR-169514

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK3	phosphorylation up-regulates →	RPTOR PSer696	phosphorylation up-regulates →	RPTOR	21071439	SIGNOR-169526
CDK1	phosphorylation up-regulates →	RPTOR PSer696	phosphorylation down-regulates ⊣	RPTOR	20169205	SIGNOR-163849
MAPK1	phosphorylation up-regulates →	RPTOR PSer696	phosphorylation down-regulates ⊣	RPTOR	21071439	SIGNOR-169514

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK3	phosphorylation → up-regulates activity	RPTOR	SIGNOR-169526
CDK1	phosphorylation → unknown	RPTOR	SIGNOR-163849
MAPK1	phosphorylation → unknown	RPTOR	SIGNOR-169514