| Name | MINK1 |
| ID | Q8N4C8 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 25-289 PROSITE-ProRule
CNH 1019-1306 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MINK1 | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276336 |
| MINK1 | PRICKLE1 | Thr370 | LSGNADDtLSRKLDD | phosphorylation up-regulates activity | 22037766 | SIGNOR-263095 |
| MINK1 | NLRP3 | – | phosphorylation up-regulates activity | 34480147 | SIGNOR-280042 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MINK1 | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276336 |
| MINK1 | phosphorylation up-regulates → | PRICKLE1 PThr370 | phosphorylation up-regulates → | PRICKLE1 | 22037766 | SIGNOR-263095 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MINK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276336 |
| MINK1 | phosphorylation → up-regulates activity | PRICKLE1 | SIGNOR-263095 |
| MINK1 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-280042 |