4.0
Summary
| Name |  MINK1View Modifications |
| Full Name | Misshapen-like kinase 1 |
| Synonyms | GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6 | B55, MAP4K6, MINK, YSK2, ZC3 |
| Primary ID | Q8N4C8 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MINK1 | down-regulates activity 
phosphorylation
|
SMAD1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MINK1 | up-regulates activity 
phosphorylation
|
PRICKLE1 | 0.294 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MINK1 | up-regulates
binding
|
KCNH2 | 0.285 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MINK1 | up-regulates activity
phosphorylation
|
NLRP3 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KRAS | up-regulates 
|
MINK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |