Entity Details

Name HASPIN
ID Q8TF76
Role substrate
Enzymatic Domains
Protein kinase 484-798
PROSITE-ProRule|
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AURKBHASPINSer143
View in OncoXplorer
PPFPSRDsGRLSPDLphosphorylation
up-regulates activity		21658950SIGNOR-263138
CDK1HASPINThr128RPPQKCStPCGPLRLphosphorylation
up-regulates activity		24413556SIGNOR-275419
PLK1HASPIN–phosphorylation
up-regulates activity		24413556SIGNOR-275421
AURKBHASPINSer93RVPKDRPsLTVTPKRphosphorylation
up-regulates activity		21658950SIGNOR-262657
AURKBHASPINSer143
View in OncoXplorer
PPFPSRDsGRLSPDLphosphorylation
up-regulates activity		21658950SIGNOR-262656
AURKBHASPINSer93RVPKDRPsLTVTPKRphosphorylation
up-regulates activity		21658950SIGNOR-263139
AURKBHASPINSer108WKLRARPsLTVTPRRphosphorylation
up-regulates activity		21658950SIGNOR-263137
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AURKBphosphorylation
up-regulates
→
HASPIN
PSer143		phosphorylation
up-regulates
→		HASPIN21658950SIGNOR-263138
CDK1phosphorylation
up-regulates
→
HASPIN
PThr128		phosphorylation
up-regulates
→		HASPIN24413556SIGNOR-275419
AURKBphosphorylation
up-regulates
→
HASPIN
PSer93		phosphorylation
up-regulates
→		HASPIN21658950SIGNOR-262657
AURKBphosphorylation
up-regulates
→
HASPIN
PSer143		phosphorylation
up-regulates
→		HASPIN21658950SIGNOR-262656
AURKBphosphorylation
up-regulates
→
HASPIN
PSer93		phosphorylation
up-regulates
→		HASPIN21658950SIGNOR-263139
AURKBphosphorylation
up-regulates
→
HASPIN
PSer108		phosphorylation
up-regulates
→		HASPIN21658950SIGNOR-263137
Regulator Mechanism/Effect Target SIGNOR-ID
AURKBphosphorylation
→
up-regulates activity 		HASPINSIGNOR-263138
CDK1phosphorylation
→
up-regulates activity 		HASPINSIGNOR-275419
PLK1phosphorylation
→
up-regulates activity 		HASPINSIGNOR-275421
AURKBphosphorylation
→
up-regulates activity 		HASPINSIGNOR-262657
AURKBphosphorylation
→
up-regulates activity 		HASPINSIGNOR-262656
AURKBphosphorylation
→
up-regulates activity 		HASPINSIGNOR-263139
AURKBphosphorylation
→
up-regulates activity 		HASPINSIGNOR-263137