Summary

Name HASPIN
Full Name Serine/threonine-protein kinase haspin
Synonyms Germ cell-specific gene 2 protein, H-haspin, Haploid germ cell-specific nuclear protein kinase | GSG2
Primary ID Q8TF76
Links - -
Type protein
Relations 10
Function Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AURKBup-regulates activity img/direct-activation.png phosphorylation HASPIN 0.2
Publications: 5 Organism: Homo Sapiens
+ CDK1up-regulates activity img/direct-activation.png phosphorylation HASPIN 0.2
Publications: 1 Organism: Homo Sapiens
+ HASPINup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Publications: 2 Organism: Homo Sapiens
+ PLK1up-regulates activity img/direct-activation.png phosphorylation HASPIN 0.2
Publications: 1 Organism: Homo Sapiens
+ HASPINup-regulates activity img/direct-activation.png binding PLK1 0.2
Publications: 1 Organism: Homo Sapiens