| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | HDAC2 | Ser394 | EDAVHEDsGDEDGED | phosphorylation up-regulates | 12082111 | SIGNOR-89937 |
| CSNK2A2 | HDAC2 | Ser394 | EDAVHEDsGDEDGED | phosphorylation up-regulates activity | 12082111 | SIGNOR-251001 |
| CSNK2A1 | HDAC2 | Ser422 | IACDEEFsDSEDEGE | phosphorylation up-regulates activity | 12082111 | SIGNOR-250887 |
| ABL1 | HDAC2 | Tyr222 | IGAGKGKyYAVNFPM | phosphorylation up-regulates quantity by stabilization | 25219501 | SIGNOR-260928 |
| CSNK2A2 | HDAC2 | Ser422 | IACDEEFsDSEDEGE | phosphorylation up-regulates activity | 12082111 | SIGNOR-251002 |
| CSNK2A2 | HDAC2 | Ser424 | CDEEFSDsEDEGEGG | phosphorylation up-regulates activity | 12082111 | SIGNOR-251003 |
| CSNK2A1 | HDAC2 | Ser394 | EDAVHEDsGDEDGED | phosphorylation up-regulates | 20388487 | SIGNOR-164795 |
| PBK | HDAC2 | – | phosphorylation up-regulates activity | 29896413 | SIGNOR-279087 | |
| PPP2CA | HDAC2 | Ser394 | EDAVHEDsGDEDGED | dephosphorylation down-regulates activity | 30050113 | SIGNOR-277049 |
| CSNK2A1 | HDAC2 | Ser424 | CDEEFSDsEDEGEGG | phosphorylation up-regulates activity | 12082111 | SIGNOR-250888 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | HDAC2 PSer394 | phosphorylation up-regulates → | HDAC2 | 12082111 | SIGNOR-89937 |
| CSNK2A2 | phosphorylation up-regulates → | HDAC2 PSer394 | phosphorylation up-regulates → | HDAC2 | 12082111 | SIGNOR-251001 |
| CSNK2A1 | phosphorylation up-regulates → | HDAC2 PSer422 | phosphorylation up-regulates → | HDAC2 | 12082111 | SIGNOR-250887 |
| ABL1 | phosphorylation up-regulates → | HDAC2 PTyr222 | phosphorylation up-regulates → | HDAC2 | 25219501 | SIGNOR-260928 |
| CSNK2A2 | phosphorylation up-regulates → | HDAC2 PSer422 | phosphorylation up-regulates → | HDAC2 | 12082111 | SIGNOR-251002 |
| CSNK2A2 | phosphorylation up-regulates → | HDAC2 PSer424 | phosphorylation up-regulates → | HDAC2 | 12082111 | SIGNOR-251003 |
| CSNK2A1 | phosphorylation up-regulates → | HDAC2 PSer394 | phosphorylation up-regulates → | HDAC2 | 20388487 | SIGNOR-164795 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC2 PSer394 | dephosphorylation up-regulates → | HDAC2 | 30050113 | SIGNOR-277049 |
| CSNK2A1 | phosphorylation up-regulates → | HDAC2 PSer424 | phosphorylation up-regulates → | HDAC2 | 12082111 | SIGNOR-250888 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates | HDAC2 | SIGNOR-89937 |
| CSNK2A2 | phosphorylation → up-regulates activity | HDAC2 | SIGNOR-251001 |
| CSNK2A1 | phosphorylation → up-regulates activity | HDAC2 | SIGNOR-250887 |
| ABL1 | phosphorylation → up-regulates quantity by stabilization | HDAC2 | SIGNOR-260928 |
| CSNK2A2 | phosphorylation → up-regulates activity | HDAC2 | SIGNOR-251002 |
| CSNK2A2 | phosphorylation → up-regulates activity | HDAC2 | SIGNOR-251003 |
| CSNK2A1 | phosphorylation → up-regulates | HDAC2 | SIGNOR-164795 |
| PBK | phosphorylation → up-regulates activity | HDAC2 | SIGNOR-279087 |
| PPP2CA | dephosphorylation → down-regulates activity | HDAC2 | SIGNOR-277049 |
| CSNK2A1 | phosphorylation → up-regulates activity | HDAC2 | SIGNOR-250888 |
