Summary

Name HDAC2
Full Name Histone deacetylase 2
Synonyms HD2
Primary ID Q92769
Links - -
Type protein
Relations 50
Inhibitors (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide; N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide; valproic acid; romidepsin; entinostat; N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide; JWOGUUIOCYMBPV-GMFLJSBRSA-N; N-[4-[(hydroxyamino)-oxomethyl]phenyl]carbamic acid [6-(diethylaminomethyl)-2-naphthalenyl]methyl ester; CUDC-101; belinostat; 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide; tacedinaline; trichostatin A; panobinostat; vorinostat; 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation HDAC2 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC2 0.618
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC2 0.391
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC2 0.618
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation HDAC2 0.285
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Epigenetic_regulation 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ form complex img/form-complex.png binding MBD3/NuRD complex 0.797
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png s-nitrosylation HDAC2 0.265
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ form complex img/form-complex.png binding MBD2/NuRD complex 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png binding CCND1 0.471
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BHC complex 0.702
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 3 Organism: In Vitro, Homo Sapiens
+ form complex img/form-complex.png binding CoREST-HDAC complex 0.704
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZNF318 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TWIST1 0.382
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI2 0.571
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HPGD 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/direct_inhibition.png deacetylation CIITA 0.414
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding HDAC2 0.471
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MECP2/SIN3A/HDAC complex 0.721
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png deacetylation YY1 0.769
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens