| Name | ARHGEF1 |
| ID | Q92888 |
| Role | substrate |
| Enzymatic Domains |
RGSL 41-232
DH 416-605 PROSITE-ProRule
PH 647-760 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | ARHGEF1 | Tyr738 | WDQEAQIyELVAQTV | phosphorylation up-regulates | 20098430 | SIGNOR-163557 |
| PRKCA | ARHGEF1 | Ser240 | TKSGDKKsGRNFFRK | phosphorylation up-regulates activity | 32881857 | SIGNOR-277530 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | ARHGEF1 PTyr738 | phosphorylation up-regulates → | ARHGEF1 | 20098430 | SIGNOR-163557 |
| PRKCA | phosphorylation up-regulates → | ARHGEF1 PSer240 | phosphorylation up-regulates → | ARHGEF1 | 32881857 | SIGNOR-277530 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates | ARHGEF1 | SIGNOR-163557 |
| PRKCA | phosphorylation → up-regulates activity | ARHGEF1 | SIGNOR-277530 |