Summary

Name ARHGEF1
Full Name Rho guanine nucleotide exchange factor 1
Synonyms 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub1.5
Primary ID Q92888
Links - -
Type protein
Relations 6
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ARHGEF1 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARHGEF1 0.587
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RHOA 0.824
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png binding, gtpase-activating protein ARHGEF1 0.587
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.824
Publications: 1 Organism: Homo Sapiens