| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 10949026 | SIGNOR-180780 |
| PPP3CC | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248528 |
| PRKCI | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 21419810 | SIGNOR-172890 |
| AKT | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 9346240 | SIGNOR-244148 |
| PKA | BAD | – | phosphorylation down-regulates | 10230396 | SIGNOR-270129 | |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10880354 | SIGNOR-250338 |
| PIM | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-259422 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 18794113 | SIGNOR-180902 |
| PRKACB | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10949026 | SIGNOR-81145 |
| Gbeta | BAD | – | phosphorylation down-regulates | 19777442 | SIGNOR-270037 | |
| PIM3 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249605 |
| RPS6KA2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-249044 |
| PRKCE | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 20179209 | SIGNOR-163916 |
| PRKACB | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81141 |
| PIM2 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249604 |
| PRKD1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 20179209 | SIGNOR-163928 |
| PRKCE | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 20179209 | SIGNOR-163908 |
| Calcineurin | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-252324 |
| PRKACG | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10949026 | SIGNOR-81157 |
| AKT | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 9381178 | SIGNOR-251469 |
| PRKCE | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 20179209 | SIGNOR-163912 |
| PRKD1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 20179209 | SIGNOR-163920 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81129 |
| RPS6KA1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-78020 |
| PIM | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-259421 |
| PIM3 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250399 |
| PRKACB | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81149 |
| PIM2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250395 |
| ERK1/2 | BAD | – | phosphorylation down-regulates activity | 8929531 | SIGNOR-244497 | |
| PRKCI | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 21419810 | SIGNOR-172886 |
| PAK5 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 12897128 | SIGNOR-250247 |
| PIM1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249607 |
| PRKACA | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 10230394 | SIGNOR-67383 |
| AKT3 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81118 |
| IKK-complex | BAD | – | phosphorylation down-regulates | 23332762 | SIGNOR-216399 | |
| IKBKB | BAD | – | phosphorylation down-regulates | 23332762 | SIGNOR-192614 | |
| PP2B | BAD | – | dephosphorylation up-regulates activity | 10195903 | SIGNOR-269992 | |
| PRKACA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10230394 | SIGNOR-67387 |
| PPP3CB | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248384 |
| PRKD1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 20179209 | SIGNOR-163924 |
| PRKCI | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 21419810 | SIGNOR-172894 |
| PPP3CA | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-263739 |
| PRKACG | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81161 |
| RPS6K | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-252786 |
| PPP3CA | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248695 |
| PIM1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250390 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10230394 | SIGNOR-67379 |
| PAK1 | BAD | Ser74 | VEIRSRHsSYPAGTE | phosphorylation down-regulates | 22096607 | SIGNOR-177271 |
| PRKACA | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 18794113 | SIGNOR-180906 |
| PPP3CB | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248383 |
| Calcineurin | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-252332 |
| AKT1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9346240 | SIGNOR-52863 |
| PRKACA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81137 |
| RPS6KA5 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 12213813 | SIGNOR-262990 |
| PIM1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250392 |
| PRKACG | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81153 |
| AKT1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 9346240 | SIGNOR-52859 |
| PIM3 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250396 |
| PRKACG | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 10949026 | SIGNOR-67400 |
| RPS6K | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 18246127 | SIGNOR-252784 |
| AKT | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9381178 | SIGNOR-251470 |
| PAK1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10611223 | SIGNOR-73533 |
| PI3K | BAD | – | phosphorylation down-regulates activity | 15526160 | SIGNOR-254951 | |
| PPP3CC | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248529 |
| PRKACG | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10230396 | SIGNOR-67392 |
| RAF1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 15849194 | SIGNOR-81165 |
| MAPK1 | BAD | – | phosphorylation down-regulates activity | 8929531 | SIGNOR-44858 | |
| RAF1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 17535812 | SIGNOR-155293 |
| AKT2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81110 |
| MAPK8 | BAD | – | phosphorylation down-regulates | 14967141 | SIGNOR-121940 | |
| AKT2 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81114 |
| PIM2 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250394 |
| IKK-complex | BAD | Ser25 | AERGLGPsPAGDGPS | phosphorylation down-regulates activity | 23332762 | SIGNOR-209776 |
| RPS6KA3 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 19282669 | SIGNOR-184595 |
| PIM | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10837473 | SIGNOR-259418 |
| PRKACG | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10230396 | SIGNOR-67396 |
| AKT3 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81122 |
| PPP3CA | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-263740 |
| CDK1 | BAD | Ser91 | EGMGEEPsPFRGRSR | phosphorylation up-regulates activity | 24677263 | SIGNOR-267921 |
| RPS6KB1 | BAD | – | phosphorylation down-regulates activity | 24771995 | SIGNOR-280016 | |
| PRKCA | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 24909179 | SIGNOR-280079 |
| RPS6KA1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 10558990 | SIGNOR-180910 |
| AKT1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 9381178 | SIGNOR-252562 |
| PPP3CA | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248694 |
| PIM | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-259423 |
| AKT1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9381178 | SIGNOR-252563 |
| PAK1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10611223 | SIGNOR-73529 |
| MAPK3 | BAD | – | phosphorylation down-regulates | 19777442 | SIGNOR-188172 | |
| AKT | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9346240 | SIGNOR-244144 |
| RPS6K | BAD | Ser153 | SWTRVFQsWWDRNLG | phosphorylation down-regulates activity | 10837486 | SIGNOR-252767 |
| RPS6KA1 | BAD | Ser153 | SWTRVFQsWWDRNLG | phosphorylation down-regulates activity | 10837486 | SIGNOR-249045 |
| RPS6KA2 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 19282669 | SIGNOR-184591 |
| RPS6KA1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 18246127 | SIGNOR-160635 |
| CHEK1 | BAD | – | phosphorylation down-regulates activity | 15736430 | SIGNOR-279159 | |
| PIM2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10837473 | SIGNOR-78015 |
| PRKCA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 24909179 | SIGNOR-280080 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-180780 |
| PPP3CC | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248528 |
| PRKCI | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 21419810 | SIGNOR-172890 |
| AKT | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-244148 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10880354 | SIGNOR-250338 |
| PIM | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259422 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 18794113 | SIGNOR-180902 |
| PRKACB | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81145 |
| PIM3 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249605 |
| RPS6KA2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-249044 |
| PRKCE | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163916 |
| PRKACB | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81141 |
| PIM2 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249604 |
| PRKD1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163928 |
| PRKCE | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163908 |
| Calcineurin | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-252324 |
| PRKACG | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81157 |
| AKT | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-251469 |
| PRKCE | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163912 |
| PRKD1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163920 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81129 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-78020 |
| PIM | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259421 |
| PIM3 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250399 |
| PRKACB | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81149 |
| PIM2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250395 |
| PRKCI | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 21419810 | SIGNOR-172886 |
| PAK5 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 12897128 | SIGNOR-250247 |
| PIM1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249607 |
| PRKACA | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10230394 | SIGNOR-67383 |
| AKT3 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81118 |
| PRKACA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10230394 | SIGNOR-67387 |
| PPP3CB | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248384 |
| PRKD1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163924 |
| PRKCI | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 21419810 | SIGNOR-172894 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-263739 |
| PRKACG | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81161 |
| RPS6K | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-252786 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248695 |
| PIM1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250390 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10230394 | SIGNOR-67379 |
| PAK1 | phosphorylation up-regulates → | BAD PSer74 | phosphorylation down-regulates ⊣ | BAD | 22096607 | SIGNOR-177271 |
| PRKACA | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18794113 | SIGNOR-180906 |
| PPP3CB | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248383 |
| Calcineurin | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-252332 |
| AKT1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-52863 |
| PRKACA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81137 |
| RPS6KA5 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 12213813 | SIGNOR-262990 |
| PIM1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250392 |
| PRKACG | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81153 |
| AKT1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-52859 |
| PIM3 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250396 |
| PRKACG | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-67400 |
| RPS6K | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18246127 | SIGNOR-252784 |
| AKT | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-251470 |
| PAK1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10611223 | SIGNOR-73533 |
| PPP3CC | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248529 |
| PRKACG | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10230396 | SIGNOR-67392 |
| RAF1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 15849194 | SIGNOR-81165 |
| RAF1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 17535812 | SIGNOR-155293 |
| AKT2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81110 |
| AKT2 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81114 |
| PIM2 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250394 |
| IKK-complex | phosphorylation up-regulates → | BAD PSer25 | phosphorylation down-regulates ⊣ | BAD | 23332762 | SIGNOR-209776 |
| RPS6KA3 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 19282669 | SIGNOR-184595 |
| PIM | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837473 | SIGNOR-259418 |
| PRKACG | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10230396 | SIGNOR-67396 |
| AKT3 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81122 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-263740 |
| CDK1 | phosphorylation up-regulates → | BAD PSer91 | phosphorylation up-regulates → | BAD | 24677263 | SIGNOR-267921 |
| PRKCA | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 24909179 | SIGNOR-280079 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10558990 | SIGNOR-180910 |
| AKT1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-252562 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248694 |
| PIM | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259423 |
| AKT1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-252563 |
| PAK1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10611223 | SIGNOR-73529 |
| AKT | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-244144 |
| RPS6K | phosphorylation up-regulates → | BAD PSer153 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-252767 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer153 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-249045 |
| RPS6KA2 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 19282669 | SIGNOR-184591 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18246127 | SIGNOR-160635 |
| PIM2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837473 | SIGNOR-78015 |
| PRKCA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 24909179 | SIGNOR-280080 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | BAD | SIGNOR-180780 |
| PPP3CC | dephosphorylation → up-regulates activity | BAD | SIGNOR-248528 |
| PRKCI | phosphorylation down-regulates | BAD | SIGNOR-172890 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-244148 |
| PKA | phosphorylation down-regulates | BAD | SIGNOR-270129 |
| PRKACA | phosphorylation → down-regulates activity | BAD | SIGNOR-250338 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259422 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-180902 |
| PRKACB | phosphorylation down-regulates | BAD | SIGNOR-81145 |
| Gbeta | phosphorylation down-regulates | BAD | SIGNOR-270037 |
| PIM3 | phosphorylation → down-regulates activity | BAD | SIGNOR-249605 |
| RPS6KA2 | phosphorylation → down-regulates activity | BAD | SIGNOR-249044 |
| PRKCE | phosphorylation down-regulates | BAD | SIGNOR-163916 |
| PRKACB | phosphorylation down-regulates | BAD | SIGNOR-81141 |
| PIM2 | phosphorylation → down-regulates activity | BAD | SIGNOR-249604 |
| PRKD1 | phosphorylation down-regulates | BAD | SIGNOR-163928 |
| PRKCE | phosphorylation down-regulates | BAD | SIGNOR-163908 |
| Calcineurin | dephosphorylation → up-regulates activity | BAD | SIGNOR-252324 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81157 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-251469 |
| PRKCE | phosphorylation down-regulates | BAD | SIGNOR-163912 |
| PRKD1 | phosphorylation down-regulates | BAD | SIGNOR-163920 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-81129 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-78020 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259421 |
| PIM3 | phosphorylation → down-regulates activity | BAD | SIGNOR-250399 |
| PRKACB | phosphorylation down-regulates | BAD | SIGNOR-81149 |
| PIM2 | phosphorylation → down-regulates activity | BAD | SIGNOR-250395 |
| ERK1/2 | phosphorylation → down-regulates activity | BAD | SIGNOR-244497 |
| PRKCI | phosphorylation down-regulates | BAD | SIGNOR-172886 |
| PAK5 | phosphorylation → down-regulates activity | BAD | SIGNOR-250247 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-249607 |
| PRKACA | phosphorylation → down-regulates activity | BAD | SIGNOR-67383 |
| AKT3 | phosphorylation down-regulates | BAD | SIGNOR-81118 |
| IKK-complex | phosphorylation down-regulates | BAD | SIGNOR-216399 |
| IKBKB | phosphorylation down-regulates | BAD | SIGNOR-192614 |
| PP2B | dephosphorylation → up-regulates activity | BAD | SIGNOR-269992 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-67387 |
| PPP3CB | dephosphorylation → up-regulates activity | BAD | SIGNOR-248384 |
| PRKD1 | phosphorylation down-regulates | BAD | SIGNOR-163924 |
| PRKCI | phosphorylation down-regulates | BAD | SIGNOR-172894 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-263739 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81161 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252786 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-248695 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-250390 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-67379 |
| PAK1 | phosphorylation down-regulates | BAD | SIGNOR-177271 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-180906 |
| PPP3CB | dephosphorylation → up-regulates activity | BAD | SIGNOR-248383 |
| Calcineurin | dephosphorylation → up-regulates activity | BAD | SIGNOR-252332 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-52863 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-81137 |
| RPS6KA5 | phosphorylation → down-regulates activity | BAD | SIGNOR-262990 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-250392 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81153 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-52859 |
| PIM3 | phosphorylation → down-regulates activity | BAD | SIGNOR-250396 |
| PRKACG | phosphorylation → down-regulates activity | BAD | SIGNOR-67400 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252784 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-251470 |
| PAK1 | phosphorylation down-regulates | BAD | SIGNOR-73533 |
| PI3K | phosphorylation → down-regulates activity | BAD | SIGNOR-254951 |
| PPP3CC | dephosphorylation → up-regulates activity | BAD | SIGNOR-248529 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-67392 |
| RAF1 | phosphorylation down-regulates | BAD | SIGNOR-81165 |
| MAPK1 | phosphorylation → down-regulates activity | BAD | SIGNOR-44858 |
| RAF1 | phosphorylation down-regulates | BAD | SIGNOR-155293 |
| AKT2 | phosphorylation down-regulates | BAD | SIGNOR-81110 |
| MAPK8 | phosphorylation down-regulates | BAD | SIGNOR-121940 |
| AKT2 | phosphorylation down-regulates | BAD | SIGNOR-81114 |
| PIM2 | phosphorylation → down-regulates activity | BAD | SIGNOR-250394 |
| IKK-complex | phosphorylation → down-regulates activity | BAD | SIGNOR-209776 |
| RPS6KA3 | phosphorylation down-regulates | BAD | SIGNOR-184595 |
| PIM | phosphorylation down-regulates | BAD | SIGNOR-259418 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-67396 |
| AKT3 | phosphorylation down-regulates | BAD | SIGNOR-81122 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-263740 |
| CDK1 | phosphorylation → up-regulates activity | BAD | SIGNOR-267921 |
| RPS6KB1 | phosphorylation → down-regulates activity | BAD | SIGNOR-280016 |
| PRKCA | phosphorylation → down-regulates activity | BAD | SIGNOR-280079 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-180910 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-252562 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-248694 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259423 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-252563 |
| PAK1 | phosphorylation down-regulates | BAD | SIGNOR-73529 |
| MAPK3 | phosphorylation down-regulates | BAD | SIGNOR-188172 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-244144 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252767 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-249045 |
| RPS6KA2 | phosphorylation down-regulates | BAD | SIGNOR-184591 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-160635 |
| CHEK1 | phosphorylation → down-regulates activity | BAD | SIGNOR-279159 |
| PIM2 | phosphorylation down-regulates | BAD | SIGNOR-78015 |
| PRKCA | phosphorylation → down-regulates activity | BAD | SIGNOR-280080 |
