Summary

Name BAD
Full Name Bcl2-associated agonist of cell death
Synonyms BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death | BBC6, BCL2L8
Primary ID Q92934
Links - -
Type protein
Relations 101
Pathways Mitochondrial Control of Apoptosis, Malignant Melanoma, Inhibition of Apoptosis
Function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.31
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.24
Publications: 6 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.24
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens, In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 4 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.49
Publications: 4 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.31
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.55
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation BAD 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation BAD 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation BAD 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation BAD 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.28
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.34
Publications: 2 Organism: , Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png binding BAD 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png BAD 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.22
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates activity img/direct-activation.png binding BAD 0.42
Publications: 1 Organism: In Vitro
Pathways:Mitochondrial Control of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png cleavage BAD 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation BAD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Proliferation 0.46
Publications: 1 Organism: Homo Sapiens
Pathways:Malignant Melanoma
+ down-regulates img/indirect_inhibition.png BAD 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png binding BCL2L2 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Survival 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding TP53 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis, Malignant Melanoma
+ up-regulates img/indirect-activation.png Apoptosis 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.22
Publications: 1 Organism: In Vitro
Pathways:Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png cleavage BAD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization BCL2 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma