| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 24909179 | SIGNOR-280079 |
| RPS6KA1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 10558990 | SIGNOR-180910 |
| AKT1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 9381178 | SIGNOR-252562 |
| PPP3CA | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248694 |
| PAK1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10611223 | SIGNOR-73529 |
| RPS6KA2 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 19282669 | SIGNOR-184591 |
| RPS6KA1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 18246127 | SIGNOR-160635 |
| PPP3CC | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248528 |
| PRKCI | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 21419810 | SIGNOR-172890 |
| PRKACB | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10949026 | SIGNOR-81145 |
| PIM3 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249605 |
| PIM2 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249604 |
| Calcineurin | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-252324 |
| PRKACG | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10949026 | SIGNOR-81157 |
| AKT | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 9381178 | SIGNOR-251469 |
| PRKCE | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 20179209 | SIGNOR-163912 |
| PIM | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-259421 |
| PAK5 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 12897128 | SIGNOR-250247 |
| PIM1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249607 |
| PRKACA | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 10230394 | SIGNOR-67383 |
| PRKD1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 20179209 | SIGNOR-163924 |
| PPP3CA | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-263739 |
| PRKACA | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 18794113 | SIGNOR-180906 |
| PPP3CB | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248383 |
| RPS6K | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 18246127 | SIGNOR-252784 |
| RAF1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 15849194 | SIGNOR-81165 |
| RPS6KA3 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 19282669 | SIGNOR-184595 |
| PRKACG | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 10230396 | SIGNOR-67396 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 24909179 | SIGNOR-280079 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10558990 | SIGNOR-180910 |
| AKT1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-252562 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248694 |
| PAK1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10611223 | SIGNOR-73529 |
| RPS6KA2 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 19282669 | SIGNOR-184591 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18246127 | SIGNOR-160635 |
| PPP3CC | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248528 |
| PRKCI | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 21419810 | SIGNOR-172890 |
| PRKACB | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81145 |
| PIM3 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249605 |
| PIM2 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249604 |
| Calcineurin | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-252324 |
| PRKACG | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81157 |
| AKT | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-251469 |
| PRKCE | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163912 |
| PIM | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259421 |
| PAK5 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 12897128 | SIGNOR-250247 |
| PIM1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249607 |
| PRKACA | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10230394 | SIGNOR-67383 |
| PRKD1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163924 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-263739 |
| PRKACA | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18794113 | SIGNOR-180906 |
| PPP3CB | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248383 |
| RPS6K | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18246127 | SIGNOR-252784 |
| RAF1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 15849194 | SIGNOR-81165 |
| RPS6KA3 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 19282669 | SIGNOR-184595 |
| PRKACG | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 10230396 | SIGNOR-67396 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → down-regulates activity | BAD | SIGNOR-280079 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-180910 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-252562 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-248694 |
| PAK1 | phosphorylation down-regulates | BAD | SIGNOR-73529 |
| RPS6KA2 | phosphorylation down-regulates | BAD | SIGNOR-184591 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-160635 |
| PPP3CC | dephosphorylation → up-regulates activity | BAD | SIGNOR-248528 |
| PRKCI | phosphorylation down-regulates | BAD | SIGNOR-172890 |
| PRKACB | phosphorylation down-regulates | BAD | SIGNOR-81145 |
| PIM3 | phosphorylation → down-regulates activity | BAD | SIGNOR-249605 |
| PIM2 | phosphorylation → down-regulates activity | BAD | SIGNOR-249604 |
| Calcineurin | dephosphorylation → up-regulates activity | BAD | SIGNOR-252324 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81157 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-251469 |
| PRKCE | phosphorylation down-regulates | BAD | SIGNOR-163912 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259421 |
| PAK5 | phosphorylation → down-regulates activity | BAD | SIGNOR-250247 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-249607 |
| PRKACA | phosphorylation → down-regulates activity | BAD | SIGNOR-67383 |
| PRKD1 | phosphorylation down-regulates | BAD | SIGNOR-163924 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-263739 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-180906 |
| PPP3CB | dephosphorylation → up-regulates activity | BAD | SIGNOR-248383 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252784 |
| RAF1 | phosphorylation down-regulates | BAD | SIGNOR-81165 |
| RPS6KA3 | phosphorylation down-regulates | BAD | SIGNOR-184595 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-67396 |
