| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9381178 | SIGNOR-252563 |
| AKT | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9346240 | SIGNOR-244144 |
| PRKCA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 24909179 | SIGNOR-280080 |
| PRKACA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 10949026 | SIGNOR-180780 |
| PIM | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-259422 |
| PRKCE | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 20179209 | SIGNOR-163916 |
| PRKD1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 20179209 | SIGNOR-163928 |
| PIM3 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250399 |
| PRKACB | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81149 |
| PRKACA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10230394 | SIGNOR-67387 |
| PPP3CB | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248384 |
| PRKCI | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 21419810 | SIGNOR-172894 |
| PRKACG | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81161 |
| PPP3CA | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248695 |
| Calcineurin | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-252332 |
| AKT1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9346240 | SIGNOR-52863 |
| PRKACA | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81137 |
| PIM1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250392 |
| PRKACG | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 10949026 | SIGNOR-67400 |
| AKT | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9381178 | SIGNOR-251470 |
| PAK1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10611223 | SIGNOR-73533 |
| PPP3CC | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-248529 |
| AKT2 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81114 |
| PIM2 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250394 |
| AKT3 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81122 |
| PPP3CA | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-263740 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-252563 |
| AKT | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-244144 |
| PRKCA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 24909179 | SIGNOR-280080 |
| PRKACA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-180780 |
| PIM | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259422 |
| PRKCE | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163916 |
| PRKD1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163928 |
| PIM3 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250399 |
| PRKACB | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81149 |
| PRKACA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10230394 | SIGNOR-67387 |
| PPP3CB | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248384 |
| PRKCI | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 21419810 | SIGNOR-172894 |
| PRKACG | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81161 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248695 |
| Calcineurin | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-252332 |
| AKT1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-52863 |
| PRKACA | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81137 |
| PIM1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250392 |
| PRKACG | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-67400 |
| AKT | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-251470 |
| PAK1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10611223 | SIGNOR-73533 |
| PPP3CC | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-248529 |
| AKT2 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81114 |
| PIM2 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250394 |
| AKT3 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81122 |
| PPP3CA | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-263740 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-252563 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-244144 |
| PRKCA | phosphorylation → down-regulates activity | BAD | SIGNOR-280080 |
| PRKACA | phosphorylation → down-regulates activity | BAD | SIGNOR-180780 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259422 |
| PRKCE | phosphorylation down-regulates | BAD | SIGNOR-163916 |
| PRKD1 | phosphorylation down-regulates | BAD | SIGNOR-163928 |
| PIM3 | phosphorylation → down-regulates activity | BAD | SIGNOR-250399 |
| PRKACB | phosphorylation down-regulates | BAD | SIGNOR-81149 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-67387 |
| PPP3CB | dephosphorylation → up-regulates activity | BAD | SIGNOR-248384 |
| PRKCI | phosphorylation down-regulates | BAD | SIGNOR-172894 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81161 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-248695 |
| Calcineurin | dephosphorylation → up-regulates activity | BAD | SIGNOR-252332 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-52863 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-81137 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-250392 |
| PRKACG | phosphorylation → down-regulates activity | BAD | SIGNOR-67400 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-251470 |
| PAK1 | phosphorylation down-regulates | BAD | SIGNOR-73533 |
| PPP3CC | dephosphorylation → up-regulates activity | BAD | SIGNOR-248529 |
| AKT2 | phosphorylation down-regulates | BAD | SIGNOR-81114 |
| PIM2 | phosphorylation → down-regulates activity | BAD | SIGNOR-250394 |
| AKT3 | phosphorylation down-regulates | BAD | SIGNOR-81122 |
| PPP3CA | dephosphorylation → up-regulates activity | BAD | SIGNOR-263740 |
