| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-259423 |
| PIM2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10837473 | SIGNOR-78015 |
| AKT | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 9346240 | SIGNOR-244148 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10880354 | SIGNOR-250338 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 18794113 | SIGNOR-180902 |
| RPS6KA2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-249044 |
| PRKACB | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81141 |
| PRKCE | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 20179209 | SIGNOR-163908 |
| PRKD1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 20179209 | SIGNOR-163920 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81129 |
| RPS6KA1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-78020 |
| PIM2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250395 |
| PRKCI | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 21419810 | SIGNOR-172886 |
| AKT3 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81118 |
| RPS6K | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-252786 |
| PIM1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250390 |
| PRKACA | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10230394 | SIGNOR-67379 |
| RPS6KA5 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 12213813 | SIGNOR-262990 |
| PRKACG | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81153 |
| AKT1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 9346240 | SIGNOR-52859 |
| PIM3 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250396 |
| PRKACG | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10230396 | SIGNOR-67392 |
| RAF1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 17535812 | SIGNOR-155293 |
| AKT2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81110 |
| PIM | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10837473 | SIGNOR-259418 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259423 |
| PIM2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837473 | SIGNOR-78015 |
| AKT | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-244148 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10880354 | SIGNOR-250338 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 18794113 | SIGNOR-180902 |
| RPS6KA2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-249044 |
| PRKACB | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81141 |
| PRKCE | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163908 |
| PRKD1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 20179209 | SIGNOR-163920 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81129 |
| RPS6KA1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-78020 |
| PIM2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250395 |
| PRKCI | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 21419810 | SIGNOR-172886 |
| AKT3 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81118 |
| RPS6K | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-252786 |
| PIM1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250390 |
| PRKACA | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10230394 | SIGNOR-67379 |
| RPS6KA5 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 12213813 | SIGNOR-262990 |
| PRKACG | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81153 |
| AKT1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-52859 |
| PIM3 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250396 |
| PRKACG | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10230396 | SIGNOR-67392 |
| RAF1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 17535812 | SIGNOR-155293 |
| AKT2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81110 |
| PIM | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837473 | SIGNOR-259418 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259423 |
| PIM2 | phosphorylation down-regulates | BAD | SIGNOR-78015 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-244148 |
| PRKACA | phosphorylation → down-regulates activity | BAD | SIGNOR-250338 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-180902 |
| RPS6KA2 | phosphorylation → down-regulates activity | BAD | SIGNOR-249044 |
| PRKACB | phosphorylation down-regulates | BAD | SIGNOR-81141 |
| PRKCE | phosphorylation down-regulates | BAD | SIGNOR-163908 |
| PRKD1 | phosphorylation down-regulates | BAD | SIGNOR-163920 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-81129 |
| RPS6KA1 | phosphorylation → down-regulates activity | BAD | SIGNOR-78020 |
| PIM2 | phosphorylation → down-regulates activity | BAD | SIGNOR-250395 |
| PRKCI | phosphorylation down-regulates | BAD | SIGNOR-172886 |
| AKT3 | phosphorylation down-regulates | BAD | SIGNOR-81118 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252786 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-250390 |
| PRKACA | phosphorylation down-regulates | BAD | SIGNOR-67379 |
| RPS6KA5 | phosphorylation → down-regulates activity | BAD | SIGNOR-262990 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-81153 |
| AKT1 | phosphorylation → down-regulates activity | BAD | SIGNOR-52859 |
| PIM3 | phosphorylation → down-regulates activity | BAD | SIGNOR-250396 |
| PRKACG | phosphorylation down-regulates | BAD | SIGNOR-67392 |
| RAF1 | phosphorylation down-regulates | BAD | SIGNOR-155293 |
| AKT2 | phosphorylation down-regulates | BAD | SIGNOR-81110 |
| PIM | phosphorylation down-regulates | BAD | SIGNOR-259418 |
