| Name | ARHGEF2 |
| ID | Q92974 |
| Role | substrate |
| Enzymatic Domains |
DH 235-432 PROSITE-ProRule
PH 472-571 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | ARHGEF2 | Ser960 | SRLSPPHsPRDFTRM | phosphorylation down-regulates activity | 17488622 | SIGNOR-276061 |
| PKN1 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 14970201 | SIGNOR-122191 |
| ERK1/2 | ARHGEF2 | – | phosphorylation up-regulates | 18211802 | SIGNOR-270138 | |
| NEK9 | ARHGEF2 | – | phosphorylation up-regulates activity | 33500736 | SIGNOR-279638 | |
| CAMK1 | ARHGEF2 | Thr103 | AALLKNNtALQSVSL | phosphorylation up-regulates activity | 28652571 | SIGNOR-279359 |
| MAPK3 | ARHGEF2 | Thr679 | PGVELLLtPREPALP | phosphorylation up-regulates | 18211802 | SIGNOR-160420 |
| AURKB | ARHGEF2 | Ser960 | SRLSPPHsPRDFTRM | phosphorylation down-regulates activity | 17488622 | SIGNOR-276062 |
| MARK2 | ARHGEF2 | Ser960 | SRLSPPHsPRDFTRM | phosphorylation down-regulates | 22072711 | SIGNOR-177100 |
| MARK2 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 22072711 | SIGNOR-177096 |
| MAPK1 | ARHGEF2 | Thr679 | PGVELLLtPREPALP | phosphorylation up-regulates | 19261619 | SIGNOR-184469 |
| PAK1 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 19667072 | SIGNOR-187573 |
| MARK3 | ARHGEF2 | Ser151 | LSLAKSVsTTNIAGH | phosphorylation up-regulates activity | 29089450 | SIGNOR-277368 |
| CyclinB/CDK1 | ARHGEF2 | Ser960 | SRLSPPHsPRDFTRM | phosphorylation down-regulates activity | 17488622 | SIGNOR-276060 |
| Gbeta | ARHGEF2 | – | phosphorylation up-regulates | 18211802 | SIGNOR-270007 | |
| PAK4 | ARHGEF2 | – | phosphorylation down-regulates activity | 23125951 | SIGNOR-279245 | |
| SRC | ARHGEF2 | Tyr198 | IDEAEVIySELMSDF | phosphorylation up-regulates activity | 31420453 | SIGNOR-277478 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | ARHGEF2 PSer960 | phosphorylation down-regulates ⊣ | ARHGEF2 | 17488622 | SIGNOR-276061 |
| PKN1 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 14970201 | SIGNOR-122191 |
| CAMK1 | phosphorylation up-regulates → | ARHGEF2 PThr103 | phosphorylation up-regulates → | ARHGEF2 | 28652571 | SIGNOR-279359 |
| MAPK3 | phosphorylation up-regulates → | ARHGEF2 PThr679 | phosphorylation up-regulates → | ARHGEF2 | 18211802 | SIGNOR-160420 |
| AURKB | phosphorylation up-regulates → | ARHGEF2 PSer960 | phosphorylation down-regulates ⊣ | ARHGEF2 | 17488622 | SIGNOR-276062 |
| MARK2 | phosphorylation up-regulates → | ARHGEF2 PSer960 | phosphorylation down-regulates ⊣ | ARHGEF2 | 22072711 | SIGNOR-177100 |
| MARK2 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 22072711 | SIGNOR-177096 |
| MAPK1 | phosphorylation up-regulates → | ARHGEF2 PThr679 | phosphorylation up-regulates → | ARHGEF2 | 19261619 | SIGNOR-184469 |
| PAK1 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 19667072 | SIGNOR-187573 |
| MARK3 | phosphorylation up-regulates → | ARHGEF2 PSer151 | phosphorylation up-regulates → | ARHGEF2 | 29089450 | SIGNOR-277368 |
| CyclinB/CDK1 | phosphorylation up-regulates → | ARHGEF2 PSer960 | phosphorylation down-regulates ⊣ | ARHGEF2 | 17488622 | SIGNOR-276060 |
| SRC | phosphorylation up-regulates → | ARHGEF2 PTyr198 | phosphorylation up-regulates → | ARHGEF2 | 31420453 | SIGNOR-277478 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation → down-regulates activity | ARHGEF2 | SIGNOR-276061 |
| PKN1 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-122191 |
| ERK1/2 | phosphorylation → up-regulates | ARHGEF2 | SIGNOR-270138 |
| NEK9 | phosphorylation → up-regulates activity | ARHGEF2 | SIGNOR-279638 |
| CAMK1 | phosphorylation → up-regulates activity | ARHGEF2 | SIGNOR-279359 |
| MAPK3 | phosphorylation → up-regulates | ARHGEF2 | SIGNOR-160420 |
| AURKB | phosphorylation → down-regulates activity | ARHGEF2 | SIGNOR-276062 |
| MARK2 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-177100 |
| MARK2 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-177096 |
| MAPK1 | phosphorylation → up-regulates | ARHGEF2 | SIGNOR-184469 |
| PAK1 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-187573 |
| MARK3 | phosphorylation → up-regulates activity | ARHGEF2 | SIGNOR-277368 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | ARHGEF2 | SIGNOR-276060 |
| Gbeta | phosphorylation → up-regulates | ARHGEF2 | SIGNOR-270007 |
| PAK4 | phosphorylation → down-regulates activity | ARHGEF2 | SIGNOR-279245 |
| SRC | phosphorylation → up-regulates activity | ARHGEF2 | SIGNOR-277478 |