Summary

Name ARHGEF2
Full Name Rho guanine nucleotide exchange factor 2
Synonyms Guanine nucleotide exchange factor H1, GEF-H1, Microtubule-regulated Rho-GEF, Proliferating cell nucleolar antigen p40 | KIAA0651, LFP40
Primary ID Q92974
Links - -
Type protein
Relations 11
Function Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARHGEF2 0.361
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGEF2 0.296
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGEF2 0.522
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.365
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.799
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARHGEF2 0.348
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ARHGEF2 0.407
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.2
Publications: 1 Organism: Homo Sapiens