| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKN1 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 14970201 | SIGNOR-122191 |
| MARK2 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 22072711 | SIGNOR-177096 |
| PAK1 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 19667072 | SIGNOR-187573 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKN1 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 14970201 | SIGNOR-122191 |
| MARK2 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 22072711 | SIGNOR-177096 |
| PAK1 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 19667072 | SIGNOR-187573 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKN1 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-122191 |
| MARK2 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-177096 |
| PAK1 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-187573 |
