| Name | SIRT1 |
| ID | Q96EB6 |
| Role | substrate |
| Enzymatic Domains |
Deacetylase sirtuin-type 236-496 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | SIRT1 | Ser540 | HVSEDSSsPERTSPP | phosphorylation up-regulates | 19107194 | SIGNOR-216841 |
| STK4 | SIRT1 | – | phosphorylation down-regulates activity | 21212262 | SIGNOR-279574 | |
| CSNK2A1 | SIRT1 | Ser661 | GAEVYSDsEDDVLSS | phosphorylation unknown | 19236849 | SIGNOR-184155 |
| MTOR | SIRT1 | Ser47 | DGPGLERsPGEPGGA | phosphorylation down-regulates activity | 21471201 | SIGNOR-280047 |
| PRKAA1 | SIRT1 | – | phosphorylation down-regulates activity | 26363315 | SIGNOR-280076 | |
| STK11 | SIRT1 | Ser615 | GEKNERTsVAGTVRK | phosphorylation up-regulates activity | 34216621 | SIGNOR-277322 |
| MAPK8 | SIRT1 | Ser47 | DGPGLERsPGEPGGA | phosphorylation up-regulates | 20027304 | SIGNOR-162318 |
| STK11 | SIRT1 | Ser732 | EAINEAIsVKQEVTD | phosphorylation up-regulates activity | 34216621 | SIGNOR-277323 |
| STK11 | SIRT1 | Ser669 | EDDVLSSsSCGSNSD | phosphorylation up-regulates activity | 34216621 | SIGNOR-277321 |
| CDK2 | SIRT1 | Ser47 | DGPGLERsPGEPGGA | phosphorylation up-regulates activity | 27991597 | SIGNOR-279513 |
| MAPK8 | SIRT1 | Ser27 | ADREAASsPAGEPLR | phosphorylation up-regulates | 20027304 | SIGNOR-162314 |
| MAPK8 | SIRT1 | Thr530 | YLSELPPtPLHVSED | phosphorylation up-regulates | 20027304 | SIGNOR-162322 |
| DYRK1A | SIRT1 | Thr530 | YLSELPPtPLHVSED | phosphorylation up-regulates activity | 20167603 | SIGNOR-278473 |
| DYRK3 | SIRT1 | – | phosphorylation up-regulates activity | 20167603 | SIGNOR-279705 | |
| STK11 | SIRT1 | – | phosphorylation up-regulates activity | 34216621 | SIGNOR-279573 | |
| CDK1 | SIRT1 | Ser540 | HVSEDSSsPERTSPP | phosphorylation up-regulates | 19107194 | SIGNOR-182863 |
| CSNK2A1 | SIRT1 | Ser659 | FHGAEVYsDSEDDVL | phosphorylation unknown | 19236849 | SIGNOR-184151 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | SIRT1 PSer540 | phosphorylation up-regulates → | SIRT1 | 19107194 | SIGNOR-216841 |
| CSNK2A1 | phosphorylation up-regulates → | SIRT1 PSer661 | phosphorylation down-regulates ⊣ | SIRT1 | 19236849 | SIGNOR-184155 |
| MTOR | phosphorylation up-regulates → | SIRT1 PSer47 | phosphorylation down-regulates ⊣ | SIRT1 | 21471201 | SIGNOR-280047 |
| STK11 | phosphorylation up-regulates → | SIRT1 PSer615 | phosphorylation up-regulates → | SIRT1 | 34216621 | SIGNOR-277322 |
| MAPK8 | phosphorylation up-regulates → | SIRT1 PSer47 | phosphorylation up-regulates → | SIRT1 | 20027304 | SIGNOR-162318 |
| STK11 | phosphorylation up-regulates → | SIRT1 PSer732 | phosphorylation up-regulates → | SIRT1 | 34216621 | SIGNOR-277323 |
| STK11 | phosphorylation up-regulates → | SIRT1 PSer669 | phosphorylation up-regulates → | SIRT1 | 34216621 | SIGNOR-277321 |
| CDK2 | phosphorylation up-regulates → | SIRT1 PSer47 | phosphorylation up-regulates → | SIRT1 | 27991597 | SIGNOR-279513 |
| MAPK8 | phosphorylation up-regulates → | SIRT1 PSer27 | phosphorylation up-regulates → | SIRT1 | 20027304 | SIGNOR-162314 |
| MAPK8 | phosphorylation up-regulates → | SIRT1 PThr530 | phosphorylation up-regulates → | SIRT1 | 20027304 | SIGNOR-162322 |
| DYRK1A | phosphorylation up-regulates → | SIRT1 PThr530 | phosphorylation up-regulates → | SIRT1 | 20167603 | SIGNOR-278473 |
| CDK1 | phosphorylation up-regulates → | SIRT1 PSer540 | phosphorylation up-regulates → | SIRT1 | 19107194 | SIGNOR-182863 |
| CSNK2A1 | phosphorylation up-regulates → | SIRT1 PSer659 | phosphorylation down-regulates ⊣ | SIRT1 | 19236849 | SIGNOR-184151 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates | SIRT1 | SIGNOR-216841 |
| STK4 | phosphorylation → down-regulates activity | SIRT1 | SIGNOR-279574 |
| CSNK2A1 | phosphorylation → unknown | SIRT1 | SIGNOR-184155 |
| MTOR | phosphorylation → down-regulates activity | SIRT1 | SIGNOR-280047 |
| PRKAA1 | phosphorylation → down-regulates activity | SIRT1 | SIGNOR-280076 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-277322 |
| MAPK8 | phosphorylation → up-regulates | SIRT1 | SIGNOR-162318 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-277323 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-277321 |
| CDK2 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-279513 |
| MAPK8 | phosphorylation → up-regulates | SIRT1 | SIGNOR-162314 |
| MAPK8 | phosphorylation → up-regulates | SIRT1 | SIGNOR-162322 |
| DYRK1A | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-278473 |
| DYRK3 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-279705 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-279573 |
| CDK1 | phosphorylation → up-regulates | SIRT1 | SIGNOR-182863 |
| CSNK2A1 | phosphorylation → unknown | SIRT1 | SIGNOR-184151 |