Summary

Name SIRT1
Full Name NAD-dependent protein deacetylase sirtuin-1
Synonyms hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2 | SIR2L1
Primary ID Q96EB6
Links - -
Type protein
Relations 55
Pathways AMPK Signaling
Inhibitors (S)-selisistat
Function NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png deacetylation EP300 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation AKT 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Heart
Pathways:AMPK Signaling
+ up-regulates activity img/direct-activation.png deacetylation AKT1 0.35
Publications: 1 Organism: Mus Musculus
Tissue: Heart
+ down-regulates activity img/direct_inhibition.png deacetylation RELA 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation NHLH2 0.22
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates activity img/direct-activation.png deacetylation XPA 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png deacetylation SMAD7 0.22
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation SIRT1 0.31
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SIRT1 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png FOXO 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates activity img/indirect_inhibition.png FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding FOXO 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png deacetylation FOXO1 0.46
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png NCOR2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png NCOR1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CLOCK/ARNTL 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png chemical activation SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png deacetylation NOTCH1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ADAMTS5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COL10A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ACAN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell Cycle Block 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation PPARGC1A 0.39
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:AMPK Signaling
+ up-regulates activity img/direct-activation.png binding SIRT1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png deacetylation FOXL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Apoptosis 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SIRT1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Cell death 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation FOXO3 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates activity img/direct-activation.png deacetylation FOXO3 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HYOU1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png MYOD1 0.28
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png deacetylation CTNNB1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png deacetylation CRTC1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PPARGC1A 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOD2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SIRT1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png deacetylation FOXO4 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deacetylation FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png deacetylation FOXO1 0.46
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates activity img/indirect_inhibition.png deacetylation FOXO3 0.53
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:AMPK Signaling