Entity Details

Name CDK2_Ser47
ID Q96EB6
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MTORSIRT1Ser47DGPGLERsPGEPGGAphosphorylation
down-regulates activity		21471201SIGNOR-280047
MAPK8SIRT1Ser47DGPGLERsPGEPGGAphosphorylation
up-regulates		20027304SIGNOR-162318
CDK2SIRT1Ser47DGPGLERsPGEPGGAphosphorylation
up-regulates activity		27991597SIGNOR-279513
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MTORphosphorylation
up-regulates
→
SIRT1
PSer47		phosphorylation
down-regulates
⊣		SIRT121471201SIGNOR-280047
MAPK8phosphorylation
up-regulates
→
SIRT1
PSer47		phosphorylation
up-regulates
→		SIRT120027304SIGNOR-162318
CDK2phosphorylation
up-regulates
→
SIRT1
PSer47		phosphorylation
up-regulates
→		SIRT127991597SIGNOR-279513
Regulator Mechanism/Effect Target SIGNOR-ID
MTORphosphorylation
→
down-regulates activity 		SIRT1SIGNOR-280047
MAPK8phosphorylation
→
up-regulates 		SIRT1SIGNOR-162318
CDK2phosphorylation
→
up-regulates activity 		SIRT1SIGNOR-279513