| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | SIRT1 | Ser540 | HVSEDSSsPERTSPP | phosphorylation up-regulates | 19107194 | SIGNOR-216841 |
| CDK1 | SIRT1 | Ser540 | HVSEDSSsPERTSPP | phosphorylation up-regulates | 19107194 | SIGNOR-182863 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | SIRT1 PSer540 | phosphorylation up-regulates → | SIRT1 | 19107194 | SIGNOR-216841 |
| CDK1 | phosphorylation up-regulates → | SIRT1 PSer540 | phosphorylation up-regulates → | SIRT1 | 19107194 | SIGNOR-182863 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates | SIRT1 | SIGNOR-216841 |
| CDK1 | phosphorylation → up-regulates | SIRT1 | SIGNOR-182863 |
