Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK8	SIRT1	Ser27 View in OncoXplorer	ADREAASsPAGEPLR	phosphorylation up-regulates	20027304	SIGNOR-162314

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK8	phosphorylation up-regulates →	SIRT1 PSer27	phosphorylation up-regulates →	SIRT1	20027304	SIGNOR-162314

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK8	phosphorylation → up-regulates	SIRT1	SIGNOR-162314