| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | CDCA5 | Ser83 | PRRSPRIsFFLEKEN | phosphorylation down-regulates activity | 23901111 | SIGNOR-276118 |
| AURKB | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276117 |
| CDK1 | CDCA5 | Ser139 | DARDLEMsKKVRRSY | phosphorylation down-regulates activity | 23901111 | SIGNOR-276125 |
| AURKB | CDCA5 | Ser33 | LRRSQRKsGSELPSI | phosphorylation down-regulates activity | 23901111 | SIGNOR-276116 |
| CDK1 | CDCA5 | Ser164 | TSTPGRRsCFGFEGL | phosphorylation down-regulates activity | 23901111 | SIGNOR-276120 |
| AURKB | CDCA5 | Ser83 | PRRSPRIsFFLEKEN | phosphorylation down-regulates activity | 23901111 | SIGNOR-276119 |
| CDK1 | CDCA5 | Ser126 | NPEAESSsKEGELDA | phosphorylation down-regulates activity | 23901111 | SIGNOR-276115 |
| ERK1/2 | CDCA5 | Ser79 | AVQSPRRsPRISFFL | phosphorylation up-regulates activity | 20551060 | SIGNOR-262969 |
| ERK1/2 | CDCA5 | Ser209 | DMTLPGIsPPPEKQK | phosphorylation up-regulates activity | 20551060 | SIGNOR-262968 |
| PLK1 | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276122 |
| CDK1 | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276121 |
| AURKB | CDCA5 | Ser126 | NPEAESSsKEGELDA | phosphorylation down-regulates activity | 23901111 | SIGNOR-276123 |
| AURKB | CDCA5 | Ser164 | TSTPGRRsCFGFEGL | phosphorylation down-regulates activity | 23901111 | SIGNOR-276113 |
| AURKB | CDCA5 | Ser139 | DARDLEMsKKVRRSY | phosphorylation down-regulates activity | 23901111 | SIGNOR-276114 |
| CDK1 | CDCA5 | Ser33 | LRRSQRKsGSELPSI | phosphorylation down-regulates activity | 23901111 | SIGNOR-276124 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | CDCA5 PSer83 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276118 |
| AURKB | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276117 |
| CDK1 | phosphorylation up-regulates → | CDCA5 PSer139 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276125 |
| AURKB | phosphorylation up-regulates → | CDCA5 PSer33 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276116 |
| CDK1 | phosphorylation up-regulates → | CDCA5 PSer164 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276120 |
| AURKB | phosphorylation up-regulates → | CDCA5 PSer83 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276119 |
| CDK1 | phosphorylation up-regulates → | CDCA5 PSer126 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276115 |
| ERK1/2 | phosphorylation up-regulates → | CDCA5 PSer79 | phosphorylation up-regulates → | CDCA5 | 20551060 | SIGNOR-262969 |
| ERK1/2 | phosphorylation up-regulates → | CDCA5 PSer209 | phosphorylation up-regulates → | CDCA5 | 20551060 | SIGNOR-262968 |
| PLK1 | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276122 |
| CDK1 | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276121 |
| AURKB | phosphorylation up-regulates → | CDCA5 PSer126 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276123 |
| AURKB | phosphorylation up-regulates → | CDCA5 PSer164 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276113 |
| AURKB | phosphorylation up-regulates → | CDCA5 PSer139 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276114 |
| CDK1 | phosphorylation up-regulates → | CDCA5 PSer33 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276124 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276118 |
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276117 |
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276125 |
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276116 |
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276120 |
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276119 |
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276115 |
| ERK1/2 | phosphorylation → up-regulates activity | CDCA5 | SIGNOR-262969 |
| ERK1/2 | phosphorylation → up-regulates activity | CDCA5 | SIGNOR-262968 |
| PLK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276122 |
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276121 |
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276123 |
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276113 |
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276114 |
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276124 |
