+ |
ERK1/2 | up-regulates activity
phosphorylation
|
CDCA5 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262968 |
Ser209 |
DMTLPGIsPPPEKQK |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
20551060 |
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Our data suggest that transactivation of CDCA5 and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation, and that the selective suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262969 |
Ser79 |
AVQSPRRsPRISFFL |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
20551060 |
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Our data suggest that transactivation of CDCA5 and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation, and that the selective suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
CDCA5 | down-regulates activity
binding
|
WAPL |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265266 |
|
|
Drosophila melanogaster |
|
pmid |
sentence |
21111234 |
We show that DNA replication and cohesin acetylation promote binding of Sororin to cohesin, and that Sororin displaces Wapl from its binding partner Pds5. |
|
Publications: |
1 |
Organism: |
Drosophila Melanogaster |