| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276117 |
| PLK1 | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276122 |
| CDK1 | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276121 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276117 |
| PLK1 | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276122 |
| CDK1 | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276121 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276117 |
| PLK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276122 |
| CDK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276121 |